Coordination Compounds of 3d Metals with 2,4-Dimethylpyrazolo[1,5-а]benzimidazole: Magnetic and Biological Properties

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Abstract

New coordination compounds of copper(I), copper(II), cobalt(II), and nickel(II) with 2,4-dimethylpyrazolo[1,5-а]benzimidazole (L) were synthesized and studied. The complexes [CuLCl] (I), [CuLBr] (II), [CuL2Cl2] (III), [CuL2(NO3)2] · H2O (IV), [CoL2Cl2] · 0,5H2O (V), [CoL2(NO3)2] · · 0,5H2O (VI), and [NiL2(NO3)2] · 0,5H2O (VII) were studied by IR spectroscopy and powder and single crystal X-ray diffraction (CCDC nos. 2321779 ([CuL2Cl2]), 2321780 ([CoL2(NO3)2])). The results indicate that the coordination polyhedron in 2,4-dimethylpyrazolo[1,5-a]benzimidazole complexes is formed by the nitrogen atoms of the monodentate ligand and the coordinated anion. The cytotoxic and cytostatic properties of L and complexes I–III were studied in relation to the HepG2 hepatocellular carcinoma cells.

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About the authors

O. G. Shakirova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences; Komsomolsk-on-Amur State University

Author for correspondence.
Email: Shakirova_Olga@mail.ru
Russian Federation, Novosibirsk; Komsomolsk-on-Amur

T. A. Kuz’menko

Institute of Physical and Organic Chemistry, Southern Federal University

Email: Shakirova_Olga@mail.ru
Russian Federation, Rostov-on-Don

N. V. Kurat’eva

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Russian Federation, Novosibirsk

L. S. Klyushova

Institute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine

Email: Shakirova_Olga@mail.ru
Russian Federation, Novosibirsk

A. N. Lavrov

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Russian Federation, Novosibirsk

L. G. Lavrenova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: ludm@niic.nsc.ru
Russian Federation, Novosibirsk

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Supplementary files

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2. Scheme 1.

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3. Scheme 2.

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4. Fig. 1. Molecular structure of the [CuL₂Cl₂] complex.

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5. Fig. 2. Crystal structure of the complex [CuL₂Cl₂

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6. Fig. 3. Hexagonal packing motif of the [CuL₂Cl₂] molecular complexes shown in the ab plane (H atoms omitted for clarity).

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7. Fig. 4. Molecular structure of the [CoL₂(NO₃)₂] complex.

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8. Fig. 5. Crystal structure of the [CoL₂(NO₃)₂] complex

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9. Fig. 6. Hexagonal packing motif of the [CoL₂(NO₃)₂] molecular complexes shown in the ab plane (H atoms omitted for clarity).

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10. Fig. 7. Diffraction patterns of complexes of the composition [CuLHal].

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11. Fig. 8. Diffraction patterns of complexes of composition [ML₂A₂].

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12. Fig. 9. Temperature dependences of the magnetic susceptibility of sample III, measured in magnetic fields H = 1, 10 kOe (a); temperature dependences of the inverse susceptibility 1/χp and the effective magnetic moment µeff, calculated in the approximation of non-interacting ions (θ = 0) (b).

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13. Fig. 10. Field dependences of magnetization M and normalized susceptibility χ(H)/χ(0) of sample III. Dashed lines show the approximation of the data by the theoretical dependence for a system of paramagnetic centers (S = 1/2, g = 2.1) with isotropic AFM interaction zJ/kB = 0.30 K. For comparison, the dotted line shows the theoretical magnetization of a system of the same paramagnetic centers with zJ/kB = 0.8 K (θ ≈ –0.4 K).

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14. Fig. 11. Effect of the studied compounds on the viability of HepG2 cells: 1 – number of cells, 2 – dead cells, 3 – living cells, 4 – apoptotic cells.

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