Synthesis, anticholinesterase and anti-radical activity of 2,3,5-trisubstituted 4H-imidazol-4-ones, green fluorescent protein chromophore analogues

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Resumo

The one-pot synthesis of N -substituted α,β-dehydrotyrosyl dipeptides was carried out by the azlactone method. The target dipeptides were obtained in good yields (53-79%). From the latter, 2,3,5-trisubstituted 4-imidazolones were obtained using 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. It was found that in the case of β-alanine-containing peptides, abstraction of the methyl ester of acrylic acid and the formation of 2,5-disubstituted 4-imidazoline were observed. Antiradical and anticholinesterase properties of the synthesized compounds were studied. Docking analysis was carried out for both some dipeptides and imidazole-4-ones.

Sobre autores

V. Topuzyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia

S. Tosunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia

A. Makichyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia;Russian-Armenian University

Email: ani.makichyan@rau.am

E. Hakobyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia

L. Galstyan

Yerevan State University

A. Hovhannisyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia

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