Development of a reproducible and scalable method for the synthesis of biologically active pyrazolo[1,5-a]pyrimidine derivatives

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Resumo

A reproducible and scalable method for the synthesis was developed, and a series of 3,6-substituted pyrazolo[1,5- a ]pyrimidines, which are the basis for the rational design of selective inhibitors of AMP-activated protein kinase, was obtained and characterized. In the course of the formation of new types of carbon skeleton, the possibility of applying Suzuki-Miyaura cross-coupling with Buchwald ligands to form C-C bond in the sterically hindered position 6 of 5,7-dimethyl-substituted pyrazolo[1,5- a ]pyrimidine was shown.

Sobre autores

D. Novikova

St. Petersburg State Institute of Technology (Technical University)

Email: dc.novikova@gmail.com

F. Darwish

St. Petersburg State Institute of Technology (Technical University)

T. Grigoreva

St. Petersburg State Institute of Technology (Technical University)

V. Tribulovich

St. Petersburg State Institute of Technology (Technical University)

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