Pyrazolines and pyrimidines based on (E)-1-(4-pentyloxyphenyl)-3-arylprop-2-en-1-ones. Synthesis, docking study and luminescent properties

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

(E)-1-(4-Pentyloxyphenyl)-3-(aryl)prop-2-en-1-ones were obtained by condensation of 1-(4-pentyloxyphenyl)ethanone with aromatic aldehydes in an aqueous ethanol solution in the presence of NaOH. The corresponding pyrazoline derivatives were prepared by cyclization of substituted chalcones with phenylhydrazine in an acidic medium, while 2,4,6-triaryl-substituted pyrimidines were produced in the case of benzamidine hydrochloride in the KOH–ethanol. It was found that all synthesized pyrazoline derivatives exhibit pronounced luminescent properties. A docking study of the compounds was carried out against four types of receptors.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Isakhanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Хат алмасуға жауапты Автор.
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-1713-4908
Армения, Yerevan

Z. Ovasyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-6698-7184
Армения, Yerevan

G. Grigoryan

Yerevan State University

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-0675-735X
Армения, Yerevan

R. Mkhitaryan

Yerevan State University

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0009-0009-6277-2747
Армения, Yerevan

L. Gabrielyan

Yerevan State University

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-9212-9682
Армения, Yerevan

G. Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-8311-6276
Армения, Yerevan

M. Dangyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-7703-1591
Армения, Yerevan

A. Sargsyan

Scientific and Production Center “Armbiotechnology” of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-7249-233X
Армения, Yerevan

A. Hambardzumyan

Scientific and Production Center “Armbiotechnology” of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-9526-7768
Армения, Yerevan

A. Harutyunyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0003-0641-5453
Армения, Yerevan

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Жүктеу
2. Fig. 1. Fluorescence spectra of samples 2–6 (1–5) in DMF solutions (c = 2·10–6 mol/l, excitation slit width – 10 nm, emission slit width – 10 nm).

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3. Fig. 2. Fluorescence spectra of samples 7–11 (1–5) in DMF solutions (c = 2·10–6 mol/l, excitation slit width – 5 nm, emission slit width – 5 nm).

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4. Fig. 3. Fluorescence spectra of samples 12, 13 and 14 (1–3) in DMF solutions (с = 2·10–6 mol/L, excitation slit width – 5 nm, emission slit width – 5 nm).

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5. Fig. 4. Fluorescence spectra of samples 15 (1) and 16 (2) in DMF solutions (с = 2·10–6 mol/l, excitation slit width – 5 nm, emission slit width – 5 nm).

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6. Fig. 5. Modes of interaction of compound 13 with RdRp, EGFR, MAPK14 and MAOB receptors.

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7. Scheme 1. R = H (2, 7, 12), OCH3 (3, 8, 13), Br (4, 9, 14), NMe2 (5, 10, 15), 1,3-бензодиоксол-5-ил (6, 11, 16).

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