Three-component synthesis and antibacterial activity of 5-Aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrroline-2-ones

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A series of new 5-aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrrolin-2-ones was synthesized by the reacting of methyl esters of aroylpyruvic acids with a mixture of aromatic aldehyde and p-anisidine. Antibacterial activity of the obtained compounds was studied in vitro against Staphylococcus aureus and Escherichia coli strains.

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作者简介

N. Kasimova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: pufmail135@gmail.com
ORCID iD: 0009-0001-6348-7333
俄罗斯联邦, Perm, 614990

O. Maiamsina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: pufmail135@gmail.com
俄罗斯联邦, Perm, 614990; Perm, 614990

S. Dubrovina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: pufmail135@gmail.com
俄罗斯联邦, Perm, 614990

V. Gein

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: pufmail135@gmail.com
ORCID iD: 0000-0002-8512-0399
俄罗斯联邦, Perm, 614990

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2. Scheme 1. R1 = ОEt, R2 = 4-Br (1); R1 = ОEt, R2 = 4-NO2 (2); R1 = Cl, R2 = H (3); R1 = NO2, R2 = H (4); R1 = ОEt, R2 = 3-NO2 (5); R1 = ОEt, R2 = 2-F (6); R1 = ОEt, R2 = H (7); R1 = NO2, R2 = 2,4-(MeO)2 (8); R1 = ОEt, R2 = 2-NO2 (9); R1 = ОEt, R2 = 4-MeO (10).

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3. Scheme 2.

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4. Scheme 3.

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