Synthesis and Biological Evaluation of  N -Aminoalkil Derivatives of Sulfanilamide Reaction

Elena A. Vasilyeva; Васильева Елена Андреевна; Irina K. Proskurina; Проскурина Ирина Константиновна; Anton А. Shetnev; Шетнев Антон Андреевич; Anna A. Romanycheva; Романычева Анна Александровна; Alyona V. Korovina; Коровина Алёна Вадимовна; Maria V. Belchenko; Бельченко Мария Владимировна; Ekaterina O. Grunina; Грунина Екатерина Олеговна; Anelle Petzer; Петцер Анель; Alexander D. Kotov; Котов Александр Дмитриевич; Jacob Petzer; Петцер Яков

doi:10.31857/S0044460X25030013

Synthesis and Biological Evaluation of N-Aminoalkil Derivatives of Sulfanilamide Reaction

Authors: Vasilyeva E.A.¹^,2, Proskurina I.K.¹, Shetnev A.А.¹^,3, Romanycheva A.A.¹, Korovina A.V.¹, Belchenko M.V.¹, Grunina E.O.¹, Petzer A.⁴, Kotov A.D.¹, Petzer J.⁴
Affiliations:
1. Ushinsky Yaroslavl State Pedagogical University
2. Kosygin Russian State University
3. Moscow Institute of Physics and Technology
4. North-West University
Issue: Vol 95, No 3-4 (2025)
Pages: 80-91
Section: Articles
URL: https://rjeid.com/0044-460X/article/view/686598
DOI: https://doi.org/10.31857/S0044460X25030013
EDN: https://elibrary.ru/DCOCLA
ID: 686598

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Abstract

A series of 19 derivatives of sulfanilamide was synthesized by the reaction of chloroacetamide, trichloroacetamide and chloropropionamide with N-nucleophiles. It was shown that N-trichloroacetylsulfanilamide in reactions with amines forms products of substitution of the trichloromethyl group, while N-chloroacetylsulfanilamide and N-chloropropionylsulfanilamide react with substitution of the halogen atom. An assessment of the antibacterial properties of the synthesized structures was carried out, showing the absence of activity with respect to E. coli and St. aureus strains. Two aminoalkyl-containing sulfonamides – 2-(4-benzylpiperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide and 2-(4-nitropyrazol-1-yl)-N-(4-sulfamoylphenyl)acetamide – showed inhibitory properties against the human monoamine oxidase enzyme, comparable in IC₅₀ value to the drug zonisamide.

Keywords

sulfonamide, N-alkylation, monoamine oxidase, inhibitor, antimicrobial activity

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References

Scholar E. // xPharm: The Comprehensive Pharmacology Reference. 2007. P. 1. doi: 10.1016/b978-008055232-3.62694-7
Курышева Н.И. // Офтальмология. 2020. Т. 17. № 4. С. 676. doi: 10.18008/1816-5095-2020-4-676-682
Abdel-Aziz A., El-Azab A.S., Abou-Zeid L.A., Eltahir K.E., Abdel-Aziz N.I., Ayyad R.R., Al-Obaid A.M. // Eur. J. Med. Chem. 2016. Vol. 115. P. 121. doi 10.1016/ j.ejmech.2016.03.011.
Bua S., Osman M., Al-Othman Z., Supuran C., Nocentini A. // Bioorg. Chem. 2019. Vol. 86. P. 39. doi 10.1016/ j.bioorg.2019.01.030
El-Azab A., Abdel-Aziz A., Bua S., Nocentini A., El-Gendy M., Mohamed M., Shawer T., Al-Saif N., Supuran C. // Bioorg. Chem. 2019. Vol. 87. P. 78. doi 10.1016/ j.bioorg.2019.03.007
Tanini D., Capperucci A., Scopelliti M., Milaneschi A., Angeli A., Supuran C. // Bioorg. Chem. 2019. Vol. 89. P. 102984. doi: 10.1016/j.bioorg.2019.102984
Krymov S.K., Salnikova D.I., Dezhenkova L.G., Bogdanov F.B., Scherbakov A.M., Shchekotikhin A.E. // Chem. Heterocycl. Compd. 2024. Vol. 60. P. 473. doi: 10.1007/s10593-024-03365-5
Kandile N.G., Elzamly R.A., Mohamed M.I., Zaky H.T., Harding D.R.K., Mohamed H.M. // Int. J. Biol. Macromol. 2023. Vol. 239. P. 1. doi: 10.1016/j.ijbiomac.2023.124280
Ibrahim H., Eldehna W., Abdel-Aziz H., Elaasser M., Abdel-Aziz M. // Eur. J. Med. Chem. 2014. Vol. 85. P. 480. doi: 10.1016/j.ejmech.2014.08.016
Singh P., Purnachander Yadav P., Swain B., Thacker P., Angeli A., Supuran C., Arifuddin M. // Bioorg. Chem. 2021. Vol. 108. Art. 104647. doi 0.1016/ j.bioorg.2021.104647
Krasavin M., Shetnev A., Baykov S., Kalinin S., Nocentini A., Sharoyko V., Poli G., Tuccinardi T., Korsakov M., Tennikova T., Supuran Claudiu T. // Eur. J. Med. Chem. 2019. Vol. 168. P. 301. doi: 10.1016/j.ejmech.2019.02.044
Turkmen H., Durgun M., Yilmaztekin S., Emul M., Innocenti A., Vullo D., Supuran C. // Bioorg. Med. Chem. Lett. 2005. Vol. 15. N 2. P. 367. doi: 10.1016/j.bmcl.2004.10.070
Georgey H., Manhi F., Mahmoud W., Mohamed N., Berrino E., Supuran C. // Bioorg. Chem. 2019. Vol. 82. P. 109. doi: 10.1016/j.bioorg.2018.09.037
Mishra C.B., Kumari S., Angeli A., Monti S.M., Buonanno M., Ti‐wari M., Supuran C. // J. Med. Chem. 2017. Vol. 60. N 6. P. 2456. doi: 10.1021/acs.jmedchem.6b01804
Hanan H., Georgey F., Manhi W., Mahmoud N., Mohamed E.B., Supuran C. // Bioorg. Chem. 2019. Vol. 82. P. 109. doi: 10.1016/j.bioorg.2018.09.037
Khokhlov A.L., Yaichkov I.I., Korsakov M.K., Shetnev A.A., Ivanovskiy S.A., Alexeev M.A., Gasilina O.A., Volkhin N.N., Petukhov S.S. // Res. Results Pharmacol. 2024. Vol. 10. N 1. P. 53. doi: 10.18413/rrpharmacology.10.431
Shetnev A., Efimova J., Gasilina O., Shabalina E., Baykov B., Lifanov D., Petersen E., Korsakov M., Petzer A., Petzer J.P. // Med. Chem. Res. 2025. Vol. 34. P. 357. doi: 10.1007/s00044-024-03346-5
Sağlık B.N., Osmaniye D., Acar Çevik U., Levent S., Kaya Çavuşoğlu B., Atlı Eklioğlu Ö., Kaplancıklı Z.A. // J. Enzyme Inhib. Med. Chem. 2020. Vol. 35. N 1. P. 1422. doi: 10.1080/14756366.2020.1784892
Alafeefy A.M., Ceruso M., Al-Tamimi A.M.S., Del Prete S., Capasso C., Supuran C. // Bioorg. Med. Chem. 2014. Vol. 22. N 19. P. 5133. doi: 10.1016/j.bmc.2014.08.015
Turkmen H., Durgun M., Yilmaztekin S., Emul M., Innocenti A., Vull D., Scozzafava A., Supuran C.T. // Bioorg. Med. Chem. Lett. 2005. Vol. 15. N 2. Р. 367. doi: 10.1016/j.bmcl.2004.10.070
Mahdy H.A., Ibrahim M.K., Metwaly A.M., Belal A., Mehany A.B.M., El-Gamal K.M.A., El-Sharkawy A., Elhendawy M.A., Radwan M.M., Elsohly M.A., Eissa I.H. // Bioorg. Chem. 2019. Vol. 94. P. 103422. doi 10.1016/ j.bioorg.2019.103422
Eissa I.H., Ibrahim M.K., Metwaly A.M., Belal A., Mehany A.B.M., Abdel‐hady A.A., Elhendawy M.A., Radwan M.M., El-Sohly M.A., Mahdy H.A. // Bioorg. Chem. 2021. Vol. 107. P. 104532. doi 10.1016/ j.bioorg.2020.104532
Monforte A.M., Ferro S., De Luca L., Lo Surdo G., Morreale F., Panne‐couque C., Balzarini J., Chimirri A. // Bioorg. Med. Chem. 2014. Vol. 22. N. 4. P. 1459. doi: 10.1016/j.bmc.2013.12.045
Kulabaş N., Tatar E., Bingöl Ö., Özsavcı D., Pannecouque C., De Clercq E., Küçükgüzel İ. // Eur. J. Med. Chem. 2016. Vol. 121. P. 58. doi 10.1016/ j.ejmech.2016.05.017
Lu X., Li X., Yang J., Huang B., Kang D., Zhao F., Zhou Z., De Clercq E., Daelemans D., Pannecouque C., Zhan P., Liu X. // Bioorg. Med. Chem. 2016. Vol. 24. N 18. P. 4424. doi 10.1016 /j.bmc.2016.07.041
Mohamed M.M., Khalil A.K., Abbass E.M., El-Naggar A.M. // Synth. Commun. 2017. Vol. 47. N 16. P. 1441. doi: 10.1080/00397911.2017.1332223
Abutayeh R.F., Almaliti J., Taha M.O. // Med. Chem. 2020. Vol. 16. N 3. P. 403. doi 10.2174/ 1573406415666190401144053
Определение чувствительности микроорганизмов к антибактериальным препаратам (МУК 4.2.1890-04) // Клин. микробиол. антимикроб. химиотер. 2004. Т. 6. Вып. 4. C. 306.
Mostert S., Petzer A., Petzer J.P. // Chem. Med. Chem. 2015. Vol. 10. P. 862. doi: 10.1002/cmdc.201500059
Sonsalla P.K., Wong L.Y., Winnik B., Buckley B. // Exp. Neurol. 2010. Vol. 221. P. 329. doi 10.1016/ j.expneurol.2009.11.018
Petzer A., Pienaar A., Petzer J.P. // Drug Res. 2013. Vol. 63. P. 462. doi: 10.1055/s-0033-1345163
Al-Sha’er M.A., Taha M.O. // Med. Chem. Res. 2011. Vol. 21. N 4. P. 487. doi: 10.1007/s00044-011-9557-9
Hu H., Bajorath J. // Mol. Pharm. 2020. Vol. 17. N 3. P. 979. doi: 10.1021/acs.molpharmaceut