Synthesis of new fused 3(4)-substituted 11-furylthieno[3,2-d]pyrimidine derivatives

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详细

A method was developed for the synthesis of new fused 3-alkyl-substituted derivatives of thieno[3,2- d ]pyrimidin-4(3 H )-ones based on 11-(2-furyl)-8,8-dimethyl-7,10-dihydro-8 H -pyrano[3′′,4′′:5′,6′]pyrido[3′,2′:4,5]-thieno[3,2- d ]pyrimidin-4(3 H )-one via nucleophilic substitution in the pyrimidine ring. A series of fused 4-amino-substituted 11-furylthieno[3,2- d ]pyrimidine derivatives was also synthesized from the corresponding 4-chloro derivative.

作者简介

V. Dabaeva

Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of the Republic of Armenia

Email: valyadabayeva@mail.ru

M. Baghdasaryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of the Republic of Armenia

I. Barkhudaryants

Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of the Republic of Armenia

E. Paronikyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of the Republic of Armenia

Sh. Dashyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Science of the Republic of Armenia

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