Development of a complex of doxorubicin with nanoparticles based on sodium alginate and viologen calix[4]resorcinol to increase selectivity of cytotoxic action

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Abstract

A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) was obtained. Using a set of physicochemical methods, the polymer- macrocycle ratio was found, at which stable nanoparticles are formed, and their morphological characteristics were determined. It was shown that with an increase in the concentration of calix[4]resorcinol, the size of nanoparticles increases and the zeta potential changes from negative to positive values. It was established that the most optimal supramolecular system for DOX binding is a composition with a macrocycle-polymer ratio of 1:50, and a change in the ratio of components can initiate drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system was shown.

About the authors

R. R Kashapov

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

Email: kashapov@iopc.ru

Yu. S. Razuvaeva

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. Yu. Ziganshina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. S Sapunova

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. D Voloshina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

V. V Salnikov

Kazan Institute of Biochemistry and Biophysics, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

L. Ya. Zakharova

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

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