On the Interaction of Gold(III) Complexes with Human Serum Albumin

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Abstract

The interaction of gold(III) complexes (Au(bipy)
, Au(phen)
, and Au(dien-H)Cl+) with human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, CNaCl = 0.2 M, CAu = (2–10) × 10–5 M, CHSA < 6 × 10–4 M) at 25°C. In all cases, gold(III) is reduced to gold(I), which forms a complex with HSA. When an excess of HSA is present, the time required for complete transformation of the complexes does not exceed 1 h. In addition, it was shown that the redox reaction of gold(III) complexes with cysteine is much faster than the reaction with methionine.

About the authors

I. V. Mironov

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: imir@niic.nsc.ru
630090, Novosibirsk, Russia

V. Yu. Kharlamova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Author for correspondence.
Email: imir@niic.nsc.ru
630090, Novosibirsk, Russia

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Copyright (c) 2023 И.В. Миронов, В.Ю. Харламова