Comparative Analysis of the Effect of Native and Polymeric β-Cyclodextrins on the Solubility and Membrane Permeability of Baricitinib

E. S. Delyagina; Делягина Е. С.; A. A. Garibyan; Гарибян А. А.; I. V. Terekhova; Терехова И. В.

doi:10.31857/S0044453723080046

Comparative Analysis of the Effect of Native and Polymeric β-Cyclodextrins on the Solubility and Membrane Permeability of Baricitinib

Autores: Delyagina E.S.¹^,2, Garibyan A.A.¹, Terekhova I.V.¹
Afiliações:
1. Institute of the Chemistry of Solutions, Krestov Academy of Sciences
2. Ivanovo State University
Edição: Volume 97, Nº 8 (2023)
Páginas: 1218-1224
Seção: БИОФИЗИЧЕСКАЯ ХИМИЯ И ФИЗИКО-ХИМИЧЕСКАЯ БИОЛОГИЯ
##submission.dateSubmitted##: 27.02.2025
##submission.datePublished##: 01.08.2023
URL: https://rjeid.com/0044-4537/article/view/668690
DOI: https://doi.org/10.31857/S0044453723080046
EDN: https://elibrary.ru/QTSHUE
ID: 668690

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Resumo

A study is performed of the effect native and polymeric β-cyclodextrins have on the solubility and membrane permeability of baricitinib, a new generation immunomodulator. It is found that native and polymeric β-cyclodextrins exhibit the same solubilizing effect in relation to baricitinib, while their effect on the membrane permeability of the drug differs. The increased solubility of baricitinib is due to the formation of inclusion complexes that have the same stability but are enthalpy-entropy stabilized in native β-cyclodextrin and enthalpy stabilized in polymeric β-cyclodextrin. The effect cyclodextrins on baricitinib’s coefficients of permeability of through a model membrane is discussed in terms of complexation, changes in the viscosity of the medium, and the state of the water boundary layer near the membrane’s surface.

Palavras-chave

solubility, immunomodulator, baricitinib, native and polymeric β-cyclodextrins

Bibliografia

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