Synaptic aspects of the pathogenesis of autism, amyotrophic lateral sclerosis, and Alzheimer’s disease

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Abstract

Recently, there has been evidence that alterations in functionality of synapses both at the pre- and postsynaptic level play an important role in the pathogenesis of many neurodegenerative diseases and autism spectrum disorders. Of particular interest may be the data on synaptic defects appearing in the early, asymptomatic stages of the disease, when it might still be possible to prevent mass degeneration of neurons. Probably, modulation of synaptic signal transduction at this stage is very effective through therapy of a number of similar diseases. This review aims to explore the role of synaptic structures in the pathogenesis of Alzheimer's disease, amyotrophic lateral sclerosis and autism spectrum disorders.

About the authors

A. E Khairullin

Kazan State Medical University;Kazan Federal University

Email: khajrulli@yandex.ru
Kazan, Russia

M. A Mukhamedyarov

Kazan State Medical University

Kazan, Russia

S. N Grishin

Kazan State Medical University

Kazan, Russia

A. Yu Teplov

Kazan State Medical University

Kazan, Russia

K. K Nagiev

Kazan State Medical University

Kazan, Russia

A. U Ziganshin

Kazan State Medical University

Kazan, Russia

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