Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4264010.17816/EID42640Review ArticleTHE PATIENT HAS LISTERIOSIS MENINGITIS AT 33-34 WEEKS OF PREGNANCY. THEMULTIDISCIPLINARY SOLUTIONSozaevaLarisa G.MDof the Department of Obstetrics and Gynecology FSBEI FPE Russian Medical Academy of Postgraduate Education Federation MOH Russia, 125993 Moscowsozaewa@mail.ruTetovaV. B-KuznetsovR. E-SamorukovV. Y-TumgoevaL. B-MassE. E-FSBEI FPE Russian Medical Academy of Postgraduate Education Federation MOH RussiaCity Clinical Hospital named after S.P. Botkin MHDFSAEIOFHE First Moscow State Medical University named after I.M. Sechenov MOH Russia15022018231303921082020Copyright © 2018, Eco-vector2018In connection both with the continuing prevalence of the listeriosis disease, and polymorphism of clinical manifestations, as well as the high lethality rate, it is necessary to better understand this problem. Listeriosis infection often affects patients with the weakened immunity, the elderly persons, pregnant women, and newborns. In particular, in pregnant women, the risk of infection with listeriosis is 18 times higher than in the general population. This feature is due to cell-mediated immune suppression in pregnant women and placental tropism of the causative agent of listeriosis L. monocytogenes. The problem of listeriosis during pregnancy includes the maternal, fetal and neonatal disease. Listeriosis in a pregnant woman is usually characterized by a sharp onset, rapid development, and a high incidence, and often it does not take much trouble. Along with this, there are cases of asymptomatic, complicated and atypical variants of the disease, which requires a high degree of clinical awareness of various specialists and the implementation of adequate screening. Fetal listeriosis is characterized by the high mortality rate amounting to up 25-35%, depending on the gestational age at the time of the onset of infection. Clinical manifestations of listeriosis in newborn infants depend on the time and pathway of infection (antenatal or intranatal infection). Neonatal listeriosis can manifest as sepsis or meningitis with severe consequences and high mortality rate (up to 20%). The appropriate treatment of maternal listeriosis is aimed at preventing the fetal disease, it also has important therapeutic value for newborn babies. The empirical use of antibiotics may appear to be ineffective for listeria. Amoxicillin or ampicillin are at the first line of the treatment in pregnant women, alone or in the combination with gentamycin, followed by trimethoprim /sulfamethoxazole. The aim of the work is to summarize the available knowledge about the problem of listeriosis, including the features of the course of the disease during pregnancy, with presenting the example of a clinical case. The article reports a clinical case demonstrating the clinical problem of listeriogenic meningitis in a pregnant woman aged 35 years. Data showing different treatment strategies are also presented.listeriosispregnancymeningitisnewborn childrenлистериозбеременностьменингитноворождённые дети[Деконенко Е.П., Куприянова Л.В., Головатенко-Абрамов К.В. и др. Листериозный менингит и его осложнения. Неврологический журнал. 2001; 2: 23-6.][Покровский В.И., Годованный Б.А. Листериоз В кн.: Покровский В.И. (ред.) Инфекционные болезни. М.; Медицина; 1996, 291-6.][Практическое руководство по антиинфекционной хемиотерапии. Под ред. Л.С. Страчунского, Ю.Б. Белоусова, С.Н.Козлова. Смоленск, МАКМАХ, 2007.][Родина Л.В., Маненкова Г.М., Тимошков В.В. Факторы и пути заражения листериозом населения Москвы. Эпидемиология и инфекционные болезни. 2002; 4: 48-50.][Середа А.Д., Котляров В.М., Воробьев А.А., Бакулов И.А. Иммунитет при листериозе. Журнал микробиологии. 2000; 5: 98-102.][Тартаковский И.С., Малеев В.В., Ермолаева С.А. Листерии: роль в инфекционной патологии человека и лабораторная диагностика. М.; Медицина для всех; 2002.][Честнова Т.В. Диагностика листериоза у новорожденных. Эпидемиология и инфекционные болезни. 2001; 3: 45-47.][Эпидемиология и профилактика листериоза. Методические указания. М.; Федеральный ЦГСЭН МЗ России, 2002.][Ющук Н.Д., Кареткина Г.Н., Климова Е.А. и др. Листериоз: варианты клинического течения. Терапевтический архив. 2001; 11: 48-51.][Ющук Н. Д., Кареткина Г. Н., Деконенко Е. П. и др. Листериоз с поражением нервной системы. Терапевтический архив. 2007; 11: 57-60.][Под ред. Г.М. Савельевой, Г.Т. Сухих, В.Н. Серова и др. Акушерство. Национальное руководство. 2015.][Приказ Министерства здравоохранения РФ от 01.11.2012 № 572н. «Об утверждении Порядка оказания медицинской помощи по профилю «акушерство и гинекология» (за исключением использования вспомогательных репродуктивных технологий)».][Doganay M. Listeriosis: сlinical presentation. Immunol. Med. Microbiol. 2003; 31 (3): 173-5.][Girmenia C., Iori A. P., Bernasconi S., Testy A. M. et al. Listeriosis in recipientof allogeneic bone marron transplants from unrelated donors. Eur. J. Clin. Microbiol. Infect. Dis. 2000; 19 (9):711-4.][Temple M.E., Nahata M.C. Treatment of listeriosis. Ann. Pharmacoter. 2000; 34 (5): 656-61.][Madjunkov M; Chaudhry S; Ito S.Listeriosis during pregnancy. Arch Gynecol Obstet. 2017; 296(2): 143-52.][Larraín de la C D, Abarzúa C F, Jourdan H Fd, Merino O P, Belmar J C, García C P. Listeria monocytogenes infection in pregnancy: experience of Pontificia Universidad Católica de Chile University Hospital. Rev Chilena Infectol. 2008 Oct; 25(5): 336-41. Epub 2008 Oct 1.]