<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42632</article-id><article-id pub-id-type="doi">10.17816/EID42632</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">THE IMPACT OF SEASONAL FACTORS ON THE DYNAMICS OF INCIDENCE RATE OF INFECTIOUS MONONUCLEOSIS IN DIFFERENT AGE GROUPS (ON THE EXAMPLE OF NIZHNY NOVGOROD)</article-title><trans-title-group xml:lang="ru"><trans-title>ВЛИЯНИЕ СЕЗОННЫХ ФАКТОРОВ НА ДИНАМИКУ УРОВНЯ ЗАБОЛЕВАЕМОСТИ ИНФЕКЦИОННЫМ МОНОНУКЛЕОЗОМ В РАЗНЫХ ВОЗРАСТНЫХ ГРУППАХ (НА ПРИМЕРЕ НИЖНЕГО НОВГОРОДА)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Filatova</surname><given-names>E. N</given-names></name><name xml:lang="ru"><surname>Филатова</surname><given-names>Елена Николаевна</given-names></name></name-alternatives><email>filatova@nniiem.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Solntsev</surname><given-names>L. A</given-names></name><name xml:lang="ru"><surname>Солнцев</surname><given-names>Леонид Аркадьевич</given-names></name></name-alternatives><email>solntsev.l.a@nniiem.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Utkin</surname><given-names>O. V</given-names></name><name xml:lang="ru"><surname>Уткин</surname><given-names>Олег Владимирович</given-names></name></name-alternatives><email>utkin@nniiem.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.N. Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare</institution></aff><aff><institution xml:lang="ru">ФБУН «Нижегородский научно-исследовательский институт эпидемиологии и микробиологии им. акад. И.Н. Блохиной» Роспотребнадзора</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2017</year></pub-date><volume>22</volume><issue>2</issue><issue-title xml:lang="en">VOL 22, NO2 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 22, №2 (2017)</issue-title><fpage>79</fpage><lpage>85</lpage><history><date date-type="received" iso-8601-date="2020-08-21"><day>21</day><month>08</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Эко-вектор"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/42632">https://rjeid.com/1560-9529/article/view/42632</self-uri><abstract xml:lang="en"><p>Infectious mononucleosis (IM) is a widespread disease. Currently, there are no clear data on the seasonality of IM, and factors affecting on the dynamics of the disease are not determined. The aim of the study was to investigate the seasonal factors affecting on the dynamics of IM incidence rate among children and adult population of the city of Nizhny Novgorod. A retrospective analysis of the incidence rate of IM among contingents of the different age in the city of Nizhny Novgorod in 2010-2015 was executed. The highest incidence rate was shown to be observed in children aged up to 6 years. The seasonal dynamics of the incidence rate of IM in different age groups was analyzed. The seasonal component derived from the decomposition of the time series of incidence rate was used for the analysis. The presence of the spring and autumn periods of seasonal rise and summer period of seasonal fall of the incidence rate, was shown regardless of the age of the group. The change of power of the impact of seasonal factors on the incidence rate of IM was found in 2010-2015. Over 6 years the contribution of seasonal factors in the incidence rate decreased in children under 13 years and, on the contrary, increased in adolescents over 13 years and adults. The dependence of the seasonal dynamics of the incidence rate of IM on climatic factors: temperature, humidity, precipitation and insolationwas studied. In children under 6 years and adults a negative correlation of the seasonal component values and the air temperature and precipitation values was found. In children aged of 7-13 years there was established a negative correlation between seasonal incidence rate of IM values and the air temperature and insolation values, as well as the positive correlation of the humidity values. In adolescents aged of 14-17 years a negative correlation of seasonal component values and the air temperature and insolation values was found.</p></abstract><trans-abstract xml:lang="ru"><p>Инфекционный мононуклеоз (ИМ) - широко распространенное заболевание. В настоящее время отсутствуют четкие данные о сезонности ИМ, а факторы, влияющие на динамику заболеваемости, не определены. Цель исследования - изучение сезонных факторов, влияющих на динамику заболеваемости ИМ детского и взрослого населения Нижнего Новгорода. Проведен ретроспективный анализ заболеваемости ИМ разных возрастных контингентов Нижнего Новгорода в 2010-2015 гг. Показано, что чаще всего ИМ наблюдали у детей младше 6 лет. Проанализирована сезонная динамика уровня заболеваемости ИМ различных возрастных групп. Для анализа использовали сезонную компоненту, выделенную при разложении временного ряда заболеваемости. Показано наличие весеннего и осеннего периодов сезонного подъема заболеваемости и летний период сезонного понижения заболеваемости относительно тренда вне зависимости от возрастной группы. Установлено изменение силы влияния сезонных факторов на уровень заболеваемости ИМ в 2010-2015 гг. У детей младше 13 лет вклад сезонных факторов в заболеваемость на протяжении 6 лет снижался, у подростков старше 13 лет и взрослых, наоборот, возрастал. Проанализирована зависимость сезонной динамики заболеваемости ИМ от климатических факторов: температуры и влажности воздуха, количества осадков и инсоляции. У детей младше 6 лет и взрослых обнаружена отрицательная зависимость значений сезонной компоненты от температуры воздуха и количества осадков. У детей 7-13 лет установлена отрицательная зависимость значений сезонной компоненты заболеваемости ИМ от температуры воздуха и инсоляции, а также положительная зависимость от влажности воздуха. У подростков 14-17 лет выявлена отрицательная зависимость значений сезонной компоненты от температуры воздуха и инсоляции.</p></trans-abstract><kwd-group xml:lang="en"><kwd>infectious mononucleosis</kwd><kwd>incidence rate</kwd><kwd>seasonality</kwd><kwd>seasonal component</kwd><kwd>climatic factors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфекционный мононуклеоз</kwd><kwd>заболеваемость</kwd><kwd>сезонность</kwd><kwd>сезонная компонента</kwd><kwd>климатические факторы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Шарипова Е.В., Бабаченко И.В. Герпес-вирусные инфекции и инфекционный мононуклеоз (обзор литературы). Журнал инфектологии. 2013; 5 (2): 5-12.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Medović R., Igrutinović Z., Radojević-Marjanović R., Marković S., Rasković Z., Simović A. et al. Clinical and laboratory differences between Epstein-Barr and cytomegalovirus infectious mononucleosis in children. Srp. Arh. Celok. Lek. 2016; 144 (1-2): 56-62.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Wang X., Yang K., Wei C., Huang Y., Zhao D. Coinfection with EBV/CMV and other respiratory agents in children with suspected infectious mononucleosis. Virol. J. 2010; 7: 247.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Catalán P., Alba A. Prophylaxis against Epstein Barr disease in pediatric and adult patients undergoing solid organ and hematopoietic stem cells transplantation. Rev. Chil. Infectol. Órg. Soc. Chil. Infectol. 2012; 29 (Suppl. 1): S29-31.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Hoagland R.J. The transmission of infectious mononucleosis. Am. J. Med. Sci. 1955; 229 (3): 262-72.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Grinde B. Herpesviruses: latency and reactivation - viral strategies and host response. J. Oral Microbiol. 2013; 5. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809354/</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Филатова Е.Н., Уткин О.В. Современные подходы к моделированию герпесвирусной инфекции. Журнал МедиАль. 2014; 2 (12): 172-97.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Balfour H.H., Dunmire S.K., Hogquist K.A. Infectious mononucleosis. Clin. Transl. Immunol. 2015; 4 (2): e33.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Womack J., Jimenez M. Common questions about infectious mononucleosis. Am. Fam. Physician. 2015; 91 (6): 372-6.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Cengiz A.B., Cultu-Kantaroğlu O., Seçmeer G., Ceyhan M., Kara A., Gürgey A. Infectious mononucleosis in Turkish children. Turk. J. Pediatr. 2010; 52 (3): 245-54.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Davidson R.J. A survey of infectious mononucleosis in the North-East Regional Hospital Board area of Scotland, 1960-9. J. Hyg. (Lond.). 1970; 68 (3): 393-400.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Учайкин В.Ф., Нисевич Н.И., Шамшева О.В. Инфекционные болезни у детей: Учебник. М.: ГЭОТАР-Медиа; 2011.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Douglas A.S., Brown T., Reid D. Infectious mononucleosis and Hodgkin’s disease - a similar seasonality. Leuk. and Lymphoma. 1996; 23 (3-4): 323-31.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Visser E., Milne D., Collacott I., McLernon D., Counsell C., Vickers M. The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak. BMC Infect. Dis. 2014; 14: 151.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lossius A., Riise T., Pugliatti M., Bjørnevik K., Casetta I., Drulovic J. et al. Season of infectious mononucleosis and risk of multiple sclerosis at different latitudes; the EnvIMS Study. Mult. Scler. Houndmills Basingstoke Engl. 2014; 20 (6): 669-74.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Эпидемиологический атлас Приволжского федерального округа (ПФО). Available at: http://epid-atlas.nniiem.ru/</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Солнцев Л.А. Практическая реализация системы представления и оценки эпидемиологической ситуации в формате электронного атласа. В кн.: Материалы VII Всероссийской научно-практической конференции молодых ученых и специалистов Роспотребнадзора. СПб.; 2015: 188-9.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Findley D.F., Monsell B.C., Bell W.R., Otto M.C., Chen B.-C. New capabilities and methods of the X-12-ARIMA seasonal-adjustment program. J. Bus. Econ. Stat. 1998; 16 (2): 127-52.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Hjalgrim H., Friborg J., Melbye M. The epidemiology of EBV and its association with malignant disease. In: Arvin A., Campadelli-Fiume G., Mocarski E., Moore P.S., Roizman B., Whitley R. et al., eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Available at: http://www.ncbi.nlm.nih.gov/books/NBK47424/</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Luzuriaga K., Sullivan J.L. Infectious Mononucleosis. N. Engl. J. Med. 2010; 362 (21): 1993-2000.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Levine H., Mimouni D., Grotto I., Zahavi A., Ankol O., Huerta-Hartal M. Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978-2009. Eur. J. Clin. Microbiol. Infect. Dis. Off. Publ. Eur. Soc. Clin. Microbiol. 2012; 31 (5): 757-60.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Leen A.M., Sili U., Bollard C.M., Rooney C.M. Adoptive immunotherapy for herpesviruses. In: Arvin A., Campadelli-Fiume G., Mocarski E., Moore P.S., Roizman B., Whitley R. et al., eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Available at: http://www.ncbi.nlm.nih.gov/books/NBK47440/</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>George M.P., Masur H., Norris K.A., Palmer S.M., Clancy C.J., McDyer J.F. Infections in the immunosuppressed host. Ann. Am. Thorac. Soc. 2014; 11 (Suppl. 4): S211-20.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Dopico X.C., Evangelou M., Ferreira R.C., Guo H., Pekalski M.L., Smyth D.J. et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nature Commun. 2015; 6: 7000.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Norval M., McLoone P., Lesiak A., Narbutt J. The effect of chronic ultraviolet radiation on the human immune system. Photochem. and Photobiol. 2008; 84 (1): 19-28.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Schwalfenberg G.K. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Mol. Nutr. Food Res. 2011; 55 (1): 96-108.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Rucker D., Allan J.A., Fick G.H., Hanley D.A. Vitamin D insufficiency in a population of healthy western Canadians. Can. Med. Assoc. J. 2002; 166 (12): 1517-24.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Zwart S.R., Mehta S.K., Ploutz-Snyder R., Bourbeau Y., Locke J.P., Pierson D.L. et al. Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr virus reactivation. J. Nutr. 2011; 141 (4): 692-7.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Simon A.K., Hollander G.A., McMichael A. Evolution of the immune system in humans from infancy to old age. Proc. Roy. Soc. B: Biol. Sci. 2015. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707740/</mixed-citation></ref></ref-list></back></article>
