In 2013 the cholera incidence remains on an upward trend in the world (with the rate of 1,127per cent and 1,765 per cent relatively to 1961 and 2004 respectively). The features determining the positive tendency in the dynamics of cholera incidence is for the first time involvement of several countries of Northern America (Haiti, The Dominican Republic and Cuba) in the epidemic process. The use of the criterion «infection density» made it possible to reveal the peculiarities of territorial cholera distribution in 109 countries of the world. Apart from the endemic territories in India and Bangladesh, there was revealed the formation of endemic foci in twelve African countries, as well consecutive in time as stepwise spacing (in accordance with provinces, districts, states and regions of countries), dissemination of epidemic cholera which could serve the evidence of continuation of the seventh cholera pandemics. The spread of modified in genome variants of Vibrio cholerae El Tor with epidemic and pandemic potential, along with the above mentioned, determines the unfavorable forecast for cholera at the global level.