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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40788</article-id><article-id pub-id-type="doi">10.17816/EID40788</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Liver cirrhosis and hepatocellular carcinoma in patients with chronic viral hepatitis c: some epidemiologic and molecular-genetic aspects</article-title><trans-title-group xml:lang="ru"><trans-title>Цирроз печени и гепатоклеточная карцинома у пациентов с хроническим вирусным гепатитом С: эпидемиологические и молекулярно-генетические аспекты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nikolaeva</surname><given-names>L. I</given-names></name><name xml:lang="ru"><surname>Николаева</surname><given-names>Людмила Ивановна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р биол. наук, рук.лаб. генно-инженерных препаратов</p></bio><email>L.i.nikolaeva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Leybman</surname><given-names>E. A</given-names></name><name xml:lang="ru"><surname>Лейбман</surname><given-names>Елена Александровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>мл. науч. сотр. лаб. генно-инженерных препаратов; аспирант каф. инфекционных болезней у детей № 1 педиатрического фаультета</p></bio><email>dr.leybman@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sapronov</surname><given-names>G. V</given-names></name><name xml:lang="ru"><surname>Сапронов</surname><given-names>Георгий Витальевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>доцент каф. инфекционных болезней</p></bio><email>geo8@inbox.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yudin</surname><given-names>A. N</given-names></name><name xml:lang="ru"><surname>Юдин</surname><given-names>Алексей Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>ст. науч. сотр. лаб. генно-инженерных препаратов, канд. биол. наук</p></bio><email>alexudin@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">D.I. Ivanovsky Institute of Virology</institution></aff><aff><institution xml:lang="ru">ФГБУ «НИИ вирусологии им. Д.И. Ивановского» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov Russian National Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Russian Medical Academy of Post-Graduate Education</institution></aff><aff><institution xml:lang="ru">ГБОУ ДПО «Российская академия последипломного образования»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2014</year></pub-date><volume>19</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2014)</issue-title><issue-title xml:lang="ru">№2 (2014)</issue-title><fpage>40</fpage><lpage>51</lpage><history><date date-type="received" iso-8601-date="2020-07-23"><day>23</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Эко-вектор"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/40788">https://rjeid.com/1560-9529/article/view/40788</self-uri><abstract xml:lang="en"><p>The aim of this review is to analyze the modern epidemiological and molecular-genetic data concerning development of liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis C. There were considered peculiarities of the occurrence of this pathology in adult patients and children with hepatitis C.</p></abstract><trans-abstract xml:lang="ru"><p>Цель обзора - проанализировать современные эпидемиологические и молекулярно-генетические данные по развитию цирроза печени и первичной гепатоклеточной карциномы у пациентов с хроническим вирусным гепатитом С. Рассмотрены особенности распространения этой патологии у взрослых и детей.</p></trans-abstract><kwd-group xml:lang="en"><kwd>viral hepatitis C</kwd><kwd>liver cirrhosis</kwd><kwd>hepatocellular carcinoma</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вирусный гепатит С</kwd><kwd>цирроз печени</kwd><kwd>гепатоклеточная карцинома</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Мукомолов С.Л., Левакова И.А., Сулягина Л.Г., Синайская Е.В., Болсун Д.Д., Иванова Н.В. 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