Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4063510.17816/EID40635Research ArticleDengue fever in the Russian Federation in travelers, returning from Southeast Asia in 2010-2011BerilloS. Aberillo@vector.nsc.ruDeminaO. Kdemina@vector.nsc.ruTernovoyV. Atern@vector.nsc.ruShikovA. Nshikov_nsk@mail.ruSergeevaE. Iesergeeva@vector.nsc.ruDeminaA. V-KostinaN. Enekostina@vector.nsc.ruVinokurovaA. Vvinokurova_av@vector.nsc.ruMikheevV. Nvn_mikheev@vector.nsc.ruAgafonovA. Pagafonov@vector.nsc.ruSergeevA. Nan_sergeev@vector.nsc.ru15082012174121523072020Copyright © 2012, Eco-vector2012The aim of the work was the study of serum from patients with suspected dengue fever by both enzyme immunoassay and immunochromatography. Markers of dengue fever were detected in 6 of 10 travelers returning from Southeast Asia. Analysis of the of immunoglobulin M and G antibody titers ratio (IgG/IgM) showed that the five travelers were infected with dengue fever virus for the first time. At the same moment one of patients was infected with dengue virus repeatedly that is a risk factor for severe complications. Thus, early laboratory diagnosis of dengue based on the detection of NSl=antigen and IgG/IgM ratio has been shown not only to help in making a differential diagnosis, but also in saving the life of the patient, because the dengue fever is characterized by rapid progression to the development of severe complications which are not compatible with life. In cases of fever in travelers which have been coming back from countries where hemorrhagic fever is endemic, we propose to make a differential diagnosis with dengue fever that was confirmed by our study.Southeast Asiatravelersdengue feverdiagnosisЮго-Восточная Азиятуристылихорадка денгедиагностика[Каталог продукции ООО "ИнтерЛабСервис" // Сайт ИЛС. URL: http://www.interlabservice.ru/catalog/reagents/index.php? sid=678][Chanama S., Anantapreecha S., Nuegoonpipat A. et al. Analysis of specific IgM responses in secondary dengue virus infections: levels and positive rates in comparison with primary infections // J. Clin. Virol. — 2004. — Vol. 31. — P. 185—189.][Guzman M.G. Effect of age on outcome of secondary dengue 2 infections // Intern. J. Infect. Dis. — 2002. — Vol. 6. — P. 118—124.][Halstead S.B. Etiologies of the experimental dengues of Siler and Simmons // Am. J. Trop. Med. Hyg. — 1974. — Vol. 23. — P. 974—982.][Halstead S.B. Pathophysiology and pathogenesis of dengue haemorrhagic fever // Monograph on Dengue/Dengue Haemorrhagic Fever / Ed. P. Thongchareon. — New Delhi, 1993. — P. 80—103.][Innis B. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis cocirculate // Am. J. Trop. Med. Hyg. — 1989. — Vol. 40. — P. 418—427.][Jelinek T. Trends in the epidemiology of dengue fever and their relevance for importation to Europe // Euro Surveill. 2009; 14 (25): pii = 19250. URL: http://www.eurosurveillance.org/ ViewArticle.aspx?ArticleId=19250.][Kuno G., Gomez I., Gubler D.J. An ELISA procedure for the diagnosis of dengue infections // J. Virol. Meth. — 1991. — Vol. 33. — P. 101—113.][PAHO. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. (Scientific Publication N 548). — Washington, 1994.][Runge-Ranzinger S., Horstrick O., Marx M., Kroeger A. What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? // Trop. Med. Int. Hlth. — Vol. 13. — P. 1022—1041.][Sangkawibha N. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak // Am. J. Epidemiol. — 1984. — Vol. 120. — P. 653—669.][Shu Pei-Yun, Chen Li-Kuang, Chang Shu-Fen. Comparison of a capture immunoglobulin M (IgM) and IgG ELISA and non-structural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections // Clin. Diagn. Lab. Immunol. — 2003. — Vol. 10. — P. 622—630.][WHO. Dengue and dengue haemorrhagic fever // Factsheet No 117, revised январь 2012. Geneva. World Health Organization, 2012. URL: http://www.who.int/mediacentre/factsheets/fs117/en/.][WHO. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. — 2nd Ed. Geneva, 1997.][World Health Organization. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. — New Ed. — , 2009.][WHO/SEARO. Situation update of dengue in the SEA Region, 2010 // World Health Organization Regional Office for South-East Asia, 2011. URL: http://www.searo.who.int/en/Section10/ Section332.htm][WHO/SEAR. Trend of Dengue case and CFR in SEAR Countries // World Health Organization Regional Office for South-East Asia, 2011. URL: http://www.searo.who.int/en/Section10/ Section332/ Section2277_11964.htm]