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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40559</article-id><article-id pub-id-type="doi">10.17816/EID40559</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The bacterial and fungal microflora of the nail plate in patients with atopic dermatitis</article-title><trans-title-group xml:lang="ru"><trans-title>Бактериальная и грибковая микрофлора ногтевых пластинок у больных атопическим дерматитом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Arzumanyan</surname><given-names>Vera Georgievna</given-names></name><name xml:lang="ru"><surname>Арзуманян</surname><given-names>Вера Георгиевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р биол. наук, вед. науч. сотр. лаб. клинической микробиологииТелефон: 8(495)917-87-41; Учреждение РАМН НИИ вакцин и сывороток им. И. И. Мечникова РАМН</p></bio><email>instmech@iitp.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kabaeva</surname><given-names>T I</given-names></name><name xml:lang="ru"><surname>Кабаева</surname><given-names>Т И</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центр регенерации "Женес", Москва</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vartanova</surname><given-names>N O</given-names></name><name xml:lang="ru"><surname>Вартанова</surname><given-names>Н О</given-names></name></name-alternatives><bio xml:lang="ru"><p>Учреждение РАМН НИИ вакцин и сывороток им. И. И. Мечникова РАМН</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Arzumanyan</surname><given-names>V G</given-names></name><bio xml:lang="en"><p>I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name><surname>Kabayeva</surname><given-names>T I</given-names></name><bio xml:lang="en"><p>Zhenes Regeneration Center, Moscow</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Vartanova</surname><given-names>N O</given-names></name><bio xml:lang="en"><p>I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences</p></bio><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Учреждение РАМН НИИ вакцин и сывороток им. И. И. Мечникова РАМН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Центр регенерации "Женес", Москва</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Zhenes Regeneration Center, Moscow</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2011</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2011)</issue-title><issue-title xml:lang="ru">№1 (2011)</issue-title><fpage>36</fpage><lpage>38</lpage><history><date date-type="received" iso-8601-date="2020-07-23"><day>23</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ООО "Эко-вектор"</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/40559">https://rjeid.com/1560-9529/article/view/40559</self-uri><abstract xml:lang="en"><p>The microflora of affected nail plates was studied in atopic dermatitis patients with suspected onychomycosis. All the examined nail samples were shown to contain microorganisms inside keratinocytes in a group of 4 adults aged 24-35 years and 20 children aged 0.3-15 years. Two of the 24 subjects were found to have only mycotic elements; 2 had only gram-positive bacteria; the other 20 had mixed microflora. Eighteen subjects were ascertained to have yeast blastospores and 4 had dermatophyte elements. It was shown that there was no correlation between the bacterial and fungal contamination of samples (p = 0.006).
Whether it is necessary to design new topical agents to treat concomitant bacterial and fungal lesions of the nail plate is discussed in the paper.</p></abstract><trans-abstract xml:lang="ru"><p>Изучена микрофлора пораженных ногтевых пластинок больных атопическим дерматитом с подозрением на онихомикоз. Показано, что в группе из 4 взрослых в возрасте 24-35 лет и 20 детей в возрасте 0,3-15 лет все обследованные образцы ногтей содержали микроорганизмы внутри кератиноцитов. У 2 человек из 24 обнаружены только грибные элементы, у 2 - только грамположительные бактерии, у остальных 20 - смешанная микрофлора. У 18 человек обнаружены только дрожжевые бластоспоры, у 4 - элементы дерматофитов. Показано отсутствие корреляции между обсемененностью образцов бактериями и грибами (p = 0,006).
Обсуждается необходимость создания новых наружных форм препаратов для лечения сочетанных бактериально-грибковых поражений ногтевых пластинок.</p></trans-abstract><kwd-group xml:lang="en"><kwd>nails</kwd><kwd>onychomycosis</kwd><kwd>onychobacteriosis</kwd><kwd>atopic dermatitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ногти</kwd><kwd>онихомикоз</kwd><kwd>онихобактериоз</kwd><kwd>атопический дерматит</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Арзуманян В. Г. Дрожжевая микрофлора кожи и респираторного тракта при аллергических заболеваниях: Дис. ... д-ра биол. наук. - М., 2002.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Арзуманян В. Г., Кабаева Т. И., Латыпова М. Ф. Онихомикоз или онихобактериоз: дифференциальная диагностика и перспективы терапии // Пробл. мед. микол. - 2006. - № 1. - С. 24-26.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>McBride M. E., Freeman R. G., Knox J. M. Keratinophilic activity in species of Corynebacterium // Can. J. Microbiol. - 1970. - Vol. 16, N 10. - P. 1024-1025.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Mikx F. H., de Jong M. H. Keratinolytic activity of cutaneous and oral bacteria // Infect. and Immun. - 1987. - Vol. 45, N 3. - P. 621-625.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rebell G., Taplin D. Dermatophytes. Their recognition and identification. - Maiami, 1971. - P. 124.</mixed-citation></ref></ref-list></back></article>
