Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4054710.17816/EID40547Seroconversion and a rise in IgG antibody concentrations in children with infection caused human herpesvirus type 6Nikol'skiyMikhail Andreevichdb5@zdrav.spb.runicolm@inbox.ruMessoroshV Gdb5@zdrav.spb.ruMinchenkoS Idb5@zdrav.spb.ruNikolskyM AI. P. Pavlov State Medical University; N. F. Filatov Children's City Clinical Hospital Five-MessoroshV GI. P. Pavlov State Medical University; N. F. Filatov Children's City Clinical Hospital Five-MinchenkoS II. P. Pavlov State Medical University; N. F. Filatov Children's City Clinical Hospital Five-I. P. Pavlov State Medical UniversityN. F. Filatov Children's City Clinical Hospital Five15062011163151823072020Copyright © 2011, Eco-vector2011The investigation was undertaken to assess whether serodiagnosis of infection caused by human herpesvirus type 6 (HHV-6) could be made in children, by determining IgG antibodies over time. One hundred and seven patients aged 1 month to 5 years who had been admitted to the infectious hospital for complaints of fever without apparent catarrhal symptoms were examined. HHV-6 IgG antibodies were found in 50% of the patients. The presence of the antibodies directly correlated with age - more than 80% of the examinees aged above 2 years had IgG antibodies. Its laboratory diagnosis was verified in 18 patients (among them, there were 14 children with roseola, 3 with rash-free fever, and 1 with recurrent febrile convulsions). Thus, serodiagnosis of HHV-6 infection in children, by determining IgG antibodies over time, is an accessible and informative tool to diagnose exanthema subitum (roseola) or rash-free fever and allows the activity of HHV-6 infection to be followed over time.exanthema subitumhuman herpesvirus type 6febrile convulsionsвнезапная экзантемаВГЧ-6-инфекцияфебрильные судороги[Caselli E., Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7 // New Microbiol. - 2007. - Vol. 30, N 3. - P. 173-187.][Leach C. T. Human herpesvirus-6 and -7 infections in children: agents of roseola and other syndromes // Curr. Opin. Pediatr. - 2000. - Vol. 12, N 3. - P. 269-274.][Suga S., Yoshikawa T., Asano Y. et al. IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation // Microbiol. and Immunol. - 1992. - Vol. 36. - P. 495.][Yamanishi K., Okuno T., Shiraki K. et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum // Lancet. - 1988. - Vol. 1. - P. 1065.]