Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4047010.17816/EID40470Comparative results of treatment for chronic hepatitis C in HIV-infected patients receiving and not receiving highly active antiretroviral therapyMinayevaS VNizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorodmistella@yandex.ruMoshkovichG FNizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorod-GoryaevaM PNizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorod-VarlovaL VNizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorod-VoroninaI DNizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorod-Nizhni Novgorod Regional Center for Prevention and Control of AIDS and Infectious Diseases, Nizhni Novgorod15062010153353823072020Copyright © 2010, Eco-vector2010The paper presents the comparative results of treatment for chronic hepatitis C in HIV-infected patients in two groups: those who receive and do not receive highly active antiretroviral therapy (HAART). The findings indicated that the efficiency of therapy for hepatitis was comparable in both groups: the proportions of patients with a steady-state virological response who received and did not receive HAART were 34.1 and 40.9%, respectively. Some adverse reactions significantly differed in their frequency in both groups. Nevertheless, their severity was that which did not require hepatitis therapy discontinuance.chronic hepatitis CHIV infectionhighly active antiretroviral therapyхронический гепатит CВИЧ-инфекциявысокоактивная антиретровирусная терапия[Методические рекомендации Федерального научно-методического центра по профилактике и борьбе со СПИДом Роспотребнадзора "Диспансерное наблюдение, лечение и профилактика вирусных гепатитов у подростков и взрослых, больных ВИЧ-инфекцией" / Кравченко А. В., Ганкина Н. Ю., Канестри В. Г. и др. - М., 2007.][Кравченко А. В., Ганкина Н. Ю., Канестри В. Г. Особенности антиретровирусной терапии при сочетании ВИЧ-инфекции и хронического вирусного гепатита // Фарматека. - 2008. № 19. - С. 1-8.][Шахгильдян В. И. Современные подходы к лечению HCV-инфекции у ВИЧ-инфицированных // Гепатол. форум. - 2008. - № 4. - С. 16-27.][Bannister W. P., Mocroft A. et al. Opportunistic infections in immunocompromised but virologically suppressed HIV-1 infected patients // 9-th International Congress on Drug Therapy in HIV Infection, Glazgow, UK, 9-13 Nov., 2008. - Glazgow, 2008. - P. 13.][Crum N. F., Riffenburgh R. H., Wegner S. et al. Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early and late HAART eras // J. Acquir. Immune Defic. Syndr. - 2006. - Vol. 41. - P. 194-200.][Laguno M., Murillas J., Blanco J. L. et al. Peginterferon Alfa-2b plus ribavirin compared with interferon Alfa-2b plus ribavirin for treatment HIV/HCV coinfected patients // AIDS. - 2004. - Vol. 18. - P. F27-F36.][Mallolas J., Laguno M. Peginterferon Alfa-2b plus ribavirin for treatment naive patients coinfected with HCV and HIV // Expert. Rev. Antiinfect. Ther. - 2008. - Vol. 6. - P. 281-289.][Moshkovich G., Minaeva S., Tichonova E., Sandova 0. HCV Genotypes distribution in the Nizhny Novgorod area HIV-positive population // 9-th International Congress on Drug Therapy in HIV Infection, Glazgow, UK, 9-13 Nov., 2008. - Glazgow, 2008. - P. 110.][Soriano V., Barriero P., Nunez M. Management of chronic hepatitis B and C in HIV-coinfected patients // J. Antimicrob. Chemother. - 2006. - Vol. 57. - P. 815-818.]