Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4046610.17816/EID40466Association of IL1B and IL1RN gene polymorphisms with the predisposition to hemorrhagic fever with renal syndrome and with the specific features of its courseKhunafinaD Kh-KhabelovaTamara Aleksandrovnathabelova@mail.ruKutuevO I-KhunafinaD KhBashkir State Medical University, Russian Agency for Health Care-KhabelovaT ABashkir State Medical University, Russian Agency for Health Care-KutuyevO IBashkir State Medical University, Russian Agency for Health Care-Bashkir State Medical University, Russian Agency for Health Care15022010151495323072020Copyright © 2010, Eco-vector2010-511C > T and 3953C > T polymorphic loci of the IL1B gene and VNTR polymorphism in the second intron of the IL1RN gene were analyzed in 335 patients with hemorrhagic fever with renal syndrome (HFRS) and 300 seronegative donors. As compared with the controls, the patients with HFRS were significantly less frequently found to have IL1RN*I/*II genotype (p = 0.03; OR = 0.69; 95% CI 0.49-0.96) and combinations of I/II-C/T-C/C and I/II-C/ T-C/T (IL1RN*VNTR - IL1B*-511C > T - IL1B*395C > T) genotypes (p = 0.03; OR = 0.58; 95%CI 0.36-0.95 and (p = 0.008; OR = 0.53; 95% CI 0.32-0.87, respectively). IL1B*C/*T genotype at the locus -511C > T of the IL1B gene (p = 0.04; OR = 1.77; 95% CI 1.02-3.09) and combinations of C/T-I/I (IL1B*-511C > T - IL1RN*VNTR) genotypes were predominant in patients with severe HFRS (p = 0.002; OR = 2.44; 95% CI 1.38-4.29). Furthermore, the carriers of IL1B*C/*T genotype at the locus -511C > T of the IL1B gene and combinations of C/T-I/I (IL1B*-511C > T - IL1RN*VNTR) genotypes were at higher risk for infectious-toxic shock (p = 0.03; OR = 2.78; 95% CI 1.10-7.38 and (p = 0.02; OR = 2.67; 95%CI 1.15-6.13, respectively). The likelihood of disseminated intravascular coagulation was higher in individuals with a combination of T/T-C/T genotypes at the polymorphic loci -511C > T, 3953C > T of the IL1B gene (p = 0.009; OR = 6.4; 95% CI 1.45-21.3). The performed study confirms the assumption that the polymorphisms of -511C > T and 3953C > T of the IL1B and VNTR polymorphism of IL1RN gene has impact on predisposition to HFRS and the pattern of its course.polymorphismhemorrhagic fever with renal syndromeinterleukin-1βinterleukin-1β receptor antagonistполиморфизмгеморрагическая лихорадка с почечным синдромоминтерлейкин-1βрецепторный антагонист интерлейкина-1β[Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. - М., 2003.][Симбирцев А. С. // Мед. иммунол. - 2001. - Т. 3, № 3. - С. 431-438.][Arend W. P. // Cytokine & Growth Factor Rev. - 2002. - Vol. 13. - P. 323-340.][4. De Giovine F. S., Takhsh E., Blakemore A. J. et al. // Hum. Mol. Genet. - 1992. - Vol. 1. - P. 450-457.][Hurme M., Santtila S. // Eur. J. Immunol. - 1998. - Vol. 28. - P. 2598-2602.][Laurincova B. // Acta Univ. Palack. Olomuc. - 2000. - Vol. 143. - P. 19-29.][Mwantembe O., Gaillard M. C., Barkhuisen M. et al. // Immunogenetics. - 2001. - Vol. 52. - P. 249-254.][Rider L. G., Artlett C. M., Foster C. B. et al. // Clin. Exp. Immunol. - 2000. - Vol. 121. - P. 47-52.][Santtila S., Savinainen K., Hurme M. et al. // Scand. J. Immunol. - 1998. - Vol. 47. - P. 195-198.][Tarlow J. K., Blakemore A. I. F., Lennard A. et al. // Hum. Genet. - 1993. - Vol. 91. - P. 403.][Wilkinson R. J., Patel P., Llewelyn M. et al. // J. Exp. Med. - 1999. - Vol. 189, N 1. - P. 1863-1873.]