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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40454</article-id><article-id pub-id-type="doi">10.17816/EID40454</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Noroviruses as an etiological factor of acute enteric infections in Novosibirsk infants</article-title><trans-title-group xml:lang="ru"><trans-title>Нововирусы как этиологический фактор острых кишечных инфекций у детей раннего возраста в Новосибирске</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bodnev</surname><given-names>S A</given-names></name><name xml:lang="ru"><surname>Боднев</surname><given-names>С А</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maleev</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Малеев</surname><given-names>В В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центральный НИИ эпидемиологии Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhirakovskaya</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Жираковская</surname><given-names>Е В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yun</surname><given-names>T E</given-names></name><name xml:lang="ru"><surname>Юн</surname><given-names>Т Э</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tikunov</surname><given-names>A Yu</given-names></name><name xml:lang="ru"><surname>Тикунов</surname><given-names>А Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nikiforova</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Никифорова</surname><given-names>Н А</given-names></name></name-alternatives><bio xml:lang="ru"><p>МУЗ Детская городская клиническая больница № 3</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Korsakova</surname><given-names>T G</given-names></name><name xml:lang="ru"><surname>Корсакова</surname><given-names>Т Г</given-names></name></name-alternatives><bio xml:lang="ru"><p>МУЗ Детская городская клиническая больница № 3</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Klemesheva</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Клемешева</surname><given-names>В В</given-names></name></name-alternatives><bio xml:lang="ru"><p>МУЗ Детская городская клиническая больница № 3</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kachko</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Качко</surname><given-names>А В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Podkolzin</surname><given-names>A T</given-names></name><name xml:lang="ru"><surname>Подколзин</surname><given-names>А Т</given-names></name></name-alternatives><bio xml:lang="ru"><p>Центральный НИИ эпидемиологии Роспотребнадзора</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tikunova</surname><given-names>Nina Viktorovna</given-names></name><name xml:lang="ru"><surname>Тикунова</surname><given-names>Нина Викторовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р биологических наук, доц., зав. лаб. разработки средств экстренной профилактики ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора; ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</p></bio><email>vector@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Bodnev</surname><given-names>S A</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Maleyev</surname><given-names>V V</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name><surname>Zhirakovskaya</surname><given-names>Ye V</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Yun</surname><given-names>T E</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Tikunov</surname><given-names>A Yu</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Nikiforova</surname><given-names>N A</given-names></name><bio xml:lang="en"><p>Children's City Clinical Hospital Three</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name><surname>Korsakova</surname><given-names>T G</given-names></name><bio xml:lang="en"><p>Children's City Clinical Hospital Three</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name><surname>Klemesheva</surname><given-names>V V</given-names></name><bio xml:lang="en"><p>Children's City Clinical Hospital Three</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name><surname>Kachko</surname><given-names>A V</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name><surname>Podkolzin</surname><given-names>A T</given-names></name><bio xml:lang="en"><p>Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name><surname>Tikunova</surname><given-names>N V</given-names></name><bio xml:lang="en"><p>"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</p></bio><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГУН Государственный научный центр вирусологии и биотехнологии "Вектор" Роспотребнадзора</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Центральный НИИ эпидемиологии Роспотребнадзора</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">МУЗ Детская городская клиническая больница № 3</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">"Vektor" State Research Center of Virology and Biotechnology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Children's City Clinical Hospital Three</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2010</year></pub-date><volume>15</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2010)</issue-title><issue-title xml:lang="ru">№1 (2010)</issue-title><fpage>40</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2020-07-23"><day>23</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ООО "Эко-вектор"</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/40454">https://rjeid.com/1560-9529/article/view/40454</self-uri><abstract xml:lang="en"><p>A total of 1007 fecal samples from the infants admitted to the unit of enteric infections, Children's City Clinical Hospital Three, Novosibirsk, were tested for genotypes 1 and 2 noroviruses in January to December 2006. It was ascertained that 12.4% of the samples contained noroviruses, most of the detected viruses being genotype 2 noroviruses (94.4%); noroviruses along with other viral pathogens were found in 7.2% of the samples. There was an age-related association - 70% of the noroviruses were isolated from infants aged 6 to 18 months. There was a morbidity rise in December 2006 when noroviruses were identified in 39% of the samples, which allowed them to hold the lead, by outstripping the traditionally more common rotavirus infection. Twenty norovirus isolates of noroviruses were tested for nucleotide sequence in the 5'-region of the gene encoding the capsid protein. The study isolates were shown to be very close and different in nucleotide sequence by not more than 4.5%.</p></abstract><trans-abstract xml:lang="ru"><p>С января по декабрь 2006 г. на наличие норовирусов 1-го и 2-го генотипов исследовано 1007 образцов фекалий у детей раннего возраста, госпитализированных в отделение кишечных инфекций ДГКБ № 3 Новосибирска. Установлено, что 12,4% проб содержали норовирусы, причем большинство из обнаруженных вирусов являлись норовирусами 2-й геногруппы (94,4%), при этом в 7,2% проб норовирусы были выявлены совместно с другими вирусными патогенами. Наблюдалась возрастная зависимость - 70% норовирусов были выделены от детей в возрасте от 6 мес до 15 лет. Зафиксирован подъем заболеваемости в декабре 2006 г., когда норовирусы выявлялись в 39% проб, что позволило им выйти на первое место, опередив традиционно более распространенную ротавирусную инфекцию. У 20 изолятов норовирусов проведено определение нуклеотидной последовательности 5'-области гена, кодирующего белок капсида. Показано, что исследованные изоляты оказались очень близкими и различались не более чем на 4,5% нуклеотидной последовательности.</p></trans-abstract><kwd-group xml:lang="en"><kwd>enteric infections</kwd><kwd>acute gastroenteritis</kwd><kwd>noroviruses</kwd><kwd>rotaviruses</kwd><kwd>genotyping</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кишечные инфекции</kwd><kwd>острые гастроэнтериты</kwd><kwd>норовирусы</kwd><kwd>ротавирусы</kwd><kwd>генотипирование</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Каджаева Э. П., Горелов А. В., Усенко Д. В. и др. // Инфекц. бол. - 2006. - Т. 3, № 2. - С. 34-36.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Fankhauser R., Monroe S., Noel J. et al. // J. Infect. Dis. - 2002. - Vol. 186. - P. 1-7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Ho E., Cheng P., Wong D. et al. // J. Med. Virol. - 2006. - Vol. 78. - P. 1473-1479.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Jiang X., Wang J., Graham D. et al. // J. Clin. Microbiol. - 1992. - Vol. 30. - P. 2529-2534.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Lopman B., Reacher M., Duijnhoven Y. et al. // Emerg. Infect. Dis. - 2003. - Vol. 9. - P. 90-96.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Maunula L., Von Bonsdorff C. // J. Clin. Virol. - 2005. - Vol. 34. - P. 186-194.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mead P., Slutsker L., Dietz V. et al. // Emerg. Infect. Dis. - 1999. - Vol. 5. - P. 607-625.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Medici M., Martinelli M., Abelli L. et al. // J. Med. Virol. - 2006. - Vol. 78. - P. 1486-1492.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9. O'Ryan M., Mamani N., Gaggero A. et al. // J. Infect. Dis. - 2000. - Vol. 182. - P. 1519-1522.</mixed-citation></ref></ref-list></back></article>
