<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">320928</article-id><article-id pub-id-type="doi">10.17816/EID320928</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Subacute brucellosis: A case report</article-title><trans-title-group xml:lang="ru"><trans-title>Подострый бруцеллёз: случай из практики</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3168-2169</contrib-id><contrib-id contrib-id-type="spin">3312-4052</contrib-id><name-alternatives><name xml:lang="en"><surname>Shakhmardanov</surname><given-names>Murad Z.</given-names></name><name xml:lang="ru"><surname>Шахмарданов</surname><given-names>Мурад Зияудинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>mur2025@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2205-9674</contrib-id><contrib-id contrib-id-type="spin">9044-5289</contrib-id><name-alternatives><name xml:lang="en"><surname>Nikiforov</surname><given-names>Vladimir V.</given-names></name><name xml:lang="ru"><surname>Никифоров</surname><given-names>Владимир Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>v.v.nikiforov@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3541-4150</contrib-id><name-alternatives><name xml:lang="en"><surname>Tereshkin</surname><given-names>Nikita A.</given-names></name><name xml:lang="ru"><surname>Терешкин</surname><given-names>Никита Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nteryoshkin@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6723-1502</contrib-id><name-alternatives><name xml:lang="en"><surname>Shakhmardanov</surname><given-names>Shakhmardan E.</given-names></name><name xml:lang="ru"><surname>Шахмарданов</surname><given-names>Шахмардан Эльдарович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mshakhmardanov@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2098-222X</contrib-id><contrib-id contrib-id-type="spin">3692-6818</contrib-id><name-alternatives><name xml:lang="en"><surname>Skryabina</surname><given-names>Anna A.</given-names></name><name xml:lang="ru"><surname>Скрябина</surname><given-names>Анна Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>anna.skryabina.85@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2767-4868</contrib-id><contrib-id contrib-id-type="spin">8938-2621</contrib-id><name-alternatives><name xml:lang="en"><surname>Tomilin</surname><given-names>Yuri N.</given-names></name><name xml:lang="ru"><surname>Томилин</surname><given-names>Юрий Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>papa220471@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Academy of Postgraduate Education</institution></aff><aff><institution xml:lang="ru">Академия постдипломного образования ФНКЦ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Dagestan State Medical University</institution></aff><aff><institution xml:lang="ru">Дагестанский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-04-03" publication-format="electronic"><day>03</day><month>04</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-06-01" publication-format="electronic"><day>01</day><month>06</month><year>2023</year></pub-date><volume>28</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>128</fpage><lpage>133</lpage><history><date date-type="received" iso-8601-date="2023-03-06"><day>06</day><month>03</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-03-10"><day>10</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-06-01"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/320928">https://rjeid.com/1560-9529/article/view/320928</self-uri><abstract xml:lang="en"><p>Brucellosis is one of the most common zoonotic diseases worldwide. The epidemiological situation of brucellosis in the Russian Federation is characterized as unfavorable. Brucellosis remains a problem in regions with developed animal husbandry. The variety of clinical manifestations and the absence of specific symptoms of brucellosis make its diagnosis challenging. The clinical case presented in this paper illustrates the delayed diagnosis of brucellosis in a 10-year-old patient presenting with fever and enlarged lymph nodes, liver, and spleen. The failure in the provision of medical care was attributed to the lack of the alertness of doctors regarding brucellosis, insufficient interpretation of epidemiological history data, and incorrect assessment of the totality of the clinical syndrome of the disease and laboratory parameters. As a result, brucellosis was diagnosed only 6 months after disease onset. Subsequent etiotropic therapy led to the stabilization of the patient’s condition, who was discharged from the hospital with recommendations under the supervision of an infectious disease specialist.</p></abstract><trans-abstract xml:lang="ru"><p>Бруцеллёз является одним из наиболее распространённых зоонозных заболеваний в мире. Эпидемиологическая ситуация по бруцеллёзу в Российской Федерации характеризуется как неблагополучная. Особую актуальность проблема бруцеллёза сохраняет в регионах с развитым животноводством. Полиморфизм клинических проявлений и отсутствие специфических симптомов бруцеллёза затрудняют диагностику данного заболевания. Представленный в работе клинический случай иллюстрирует запоздалую диагностику бруцеллёза у пациента 10 лет с волнообразной лихорадкой, лимфаденопатией, гепатоспленомегалией. Дефекты оказания медицинской помощи были обусловлены отсутствием настороженности врачей в отношении бруцеллёза, недостаточностью интерпретации данных эпидемиологического анамнеза, неправильной оценкой совокупности клинических синдромов болезни и лабораторных показателей. В результате бруцеллёз был диагностирован лишь через полгода от начала заболевания. Последующая этиотропная терапия привела к стабилизации состояния пациента, который был выписан из стационара с рекомендацией продолжить лечение амбулаторно под наблюдением врача-инфекциониста.</p></trans-abstract><kwd-group xml:lang="en"><kwd>arthritis of the ankle joint</kwd><kwd>case report</kwd><kwd>subacute brucellosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>подострый бруцеллёз</kwd><kwd>артрит голеностопного сустава</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Khoshnood S, Pakzad R, Koupaei M, et al. Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis. Front Vet Sci. 2022;9:976215. doi: 10.3389/fvets.2022.976215</mixed-citation><mixed-citation xml:lang="ru">Khoshnood S., Pakzad R., Koupaei M., et al. Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis // Front Vet Sci. 2022. Vol. 9. P. 976215. doi: 10.3389/fvets.2022.976215</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Ponomarenko DG, Skudareva ON, Khachaturova AA, et al. Brucellosis: Trends in the Development of Situation in the World and Forecast for 2022 in the Russian Federation. Problemy Osobo Opasnykh Infektsii. 2022;2:36–45. (In Russ). doi: 10.21055/0370-1069-2022-2-36-45</mixed-citation><mixed-citation xml:lang="ru">Пономаренко Д.Г., Скударева О.Н., Хачатурова А.А., и др. Бруцеллёз: тенденции развития ситуации в мире и прогноз на 2022 г. в Российской Федерации // Проблемы особо опасных инфекций. 2022. № 2. С. 36–45. doi: 10.21055/0370-1069-2022-2-36-45</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Chislo zaregistrirovannykh sluchaev infektsionnykh zabolevanii [Internet]. Edinaya mezhvedomstvennaya informatsionno-statisticheskaya sistema [cited 2023 Mar 22]. Available from: https://www.fedstat.ru/indicator/38208?ysclid.</mixed-citation><mixed-citation xml:lang="ru">Единая межведомственная информационно-статистическая система. [интернет]. Число зарегистрированных случаев инфекционных заболеваний [дата обращения: 22.03.2023]. Доступ по ссылке: https://www.fedstat.ru/indicator/38208?ysclid.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Shakhmardanov MZ, Abusueva AS, Nikiforov VV, et al. Incidence of brucellosis in the Republic of Dagestan in 2019. Epidemiology and Infectious Diseases. 2020;25(3):112−116. (In Russ). doi: 10.17816/EID50362</mixed-citation><mixed-citation xml:lang="ru">Шахмарданов М.З., Абусуева А.С., Никифоров В.В., и др. Заболеваемость бруцеллёзом в республике Дагестан в 2019 г. // Эпидемиология и инфекционные болезни. 2020. Т. 25, № 3. С. 112–116. doi: 10.17816/EID50362</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Dzyuba GT, Skurikhina YE, Zakharova GA, Ponomareva AV. Brucellosis morbidity in Russia and Primorsky region. Pacific Medical Journal. 2021;4:50–55. (In Russ). doi: 10.34215/1609-1175-2021-4-50-55</mixed-citation><mixed-citation xml:lang="ru">Дзюба Г.Т., Скурихина Ю.Е., Захарова Г.А., Пономарёва А.В. О заболеваемости бруцеллёзом в России и в Приморском крае // Тихоокеанский медицинский журнал. 2021. № 4. С. 50–55. doi: 10.34215/1609-1175-2021-4-50-55</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Mirijello A, Ritrovato N, D’Agruma A, et al. Abdominal Lymphadenopathies: Lymphoma, Brucellosis or Tuberculosis? Multidisciplinary Approach-Case Report and Review of the Literature. Medicina (Kaunas). 2023;59(2):293. doi: 10.3390/medicina59020293</mixed-citation><mixed-citation xml:lang="ru">Mirijello A., Ritrovato N., D’Agruma A., et al. Abdominal Lymphadenopathies: Lymphoma, Brucellosis or Tuberculosis? Multidisciplinary Approach-Case Report and Review of the Literature // Medicina (Kaunas). 2023. Vol. 59, N 2. P. 293. doi: 10.3390/medicina59020293</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Sharif A, Heravi MM, Barahimi E, et al. Brucellosis presenting with sepsis and cholestasis: A rare presentation of an endemic disease with review of the literature. IDCases. 2022;29:e01519. doi: 10.1016/j.idcr.2022.e01519</mixed-citation><mixed-citation xml:lang="ru">Sharif A., Heravi M.M., Barahimi E., et al. Brucellosis presenting with sepsis and cholestasis: A rare presentation of an endemic disease with review of the literature // IDCases. 2022. Vol. 29. P. e01519. doi: 10.1016/j.idcr.2022.e01519</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Doya LJ, Haidar I, Sakkour S. The association between acute brucellosis with a Guillain-Barré syndrome-like presentation: a case report. J Med Case Rep. 2023;17(1):25. doi: 10.1186/s13256-022-03740-w</mixed-citation><mixed-citation xml:lang="ru">Doya L.J., Haidar I., Sakkour S. The association between acute brucellosis with a Guillain-Barré syndrome-like presentation: a case report // J Med Case Rep. 2023. Vol. 17, N 1. P. 25. doi: 10.1186/s13256-022-03740-w</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Yildirim AA, Kurt C, Çetinkol Y. Brucellosis with rare complications and review of diagnostic tests: a case report. J Med Case Rep. 2022;16(1):492. doi: 10.1186/s13256-022-03702-2</mixed-citation><mixed-citation xml:lang="ru">Yildirim A.A., Kurt C., Çetinkol Y. Brucellosis with rare complications and review of diagnostic tests: a case report // J Med Case Rep. 2022. Vol. 16, N 1. P. 492. doi: 10.1186/s13256-022-03702-2</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Kulakov YuK, Dalgatova AA, Burgasova OA, Bacalin VV. Particular qualities of laboratory approaches in complex diagnosis of human brucellosis. Epidemiology and Infectious Diseases. 2021;26(4): 141–154. (In Russ). doi: 10.17816/EID108212</mixed-citation><mixed-citation xml:lang="ru">Кулаков Ю.К., Далгатова А.А., Бургасова О.А., Бакалин В.В. Особенности лабораторных подходов в комплексной диагностике бруцеллёза у людей // Эпидемиология и инфекционные болезни. 2021. Т. 26, № 4. С. 141–154. doi: 10.17816/EID108212</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Kurmanov B, Zincke D, Su W, et al. Assays for Identification and Differentiation of Brucella Species: A Review. Microorganisms. 2022;10(8):1584. doi: 10.3390/microorganisms10081584</mixed-citation><mixed-citation xml:lang="ru">Kurmanov B., Zincke D., Su W., et al. Assays for Identification and Differentiation of Brucella Species: A Review // Microorganisms. 2022. Vol. 10, N 8. P. 1584. doi: 10.3390/microorganisms10081584</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Kydyshov K, Usenbaev N, Sharshenbekov A, et al. Brucellosis in Humans and Animals in Kyrgyzstan. Microorganisms. 2022; 10(7):1293. doi: 10.3390/microorganisms10071293</mixed-citation><mixed-citation xml:lang="ru">Kydyshov K., Usenbaev N., Sharshenbekov A., et al. Brucellosis in Humans and Animals in Kyrgyzstan // Microorganisms. 2022. Vol. 10, N 7. P. 1293. doi: 10.3390/microorganisms10071293</mixed-citation></citation-alternatives></ref></ref-list></back></article>
