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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">278272</article-id><article-id pub-id-type="doi">10.17816/EID278272</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Mixed infection with COVID-19 and tropical malaria (case report)</article-title><trans-title-group xml:lang="ru"><trans-title>Микст-инфекция COVID-19 и тропической малярии (клинический случай)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7889-6052</contrib-id><contrib-id contrib-id-type="spin">7115-2713</contrib-id><name-alternatives><name xml:lang="en"><surname>Efremov</surname><given-names>Dmitriy O.</given-names></name><name xml:lang="ru"><surname>Ефремов</surname><given-names>Дмитрий Олегович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>Efremov-d24@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-7956-4694</contrib-id><contrib-id contrib-id-type="spin">6195-3308</contrib-id><name-alternatives><name xml:lang="en"><surname>Khuramshin</surname><given-names>Ainur R.</given-names></name><name xml:lang="ru"><surname>Хурамшин</surname><given-names>Айнур Разифович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ainur83@inbox.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0632-7306</contrib-id><contrib-id contrib-id-type="spin">5519-6057</contrib-id><name-alternatives><name xml:lang="en"><surname>Кozlov</surname><given-names>Sergey S.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Сергей Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>infectology@mail.ru</email><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7578-8715</contrib-id><contrib-id contrib-id-type="spin">2507-5073</contrib-id><name-alternatives><name xml:lang="en"><surname>Gulyaev</surname><given-names>Nikolay I.</given-names></name><name xml:lang="ru"><surname>Гуляев</surname><given-names>Николай Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><email>nig27@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Medical Research Center for High Medical Technologies ― Central Military Clinical Hospital named after A.A. Vishnevsky</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр высоких медицинских технологий ― Центральный военный клинический госпиталь имени А.А. Вишневского</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Medical Research Center for High Medical Technologies ― Central Military Clinical Hospital named after A.A. Vishnevsky</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр высоких медицинских технологий ― Центральный военный клинический госпиталь имени А.А. Вишневского</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kirov Military Medical Academy</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия имени С.М. Кирова</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Saint-Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный медицинский педиатрический университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-03-14" publication-format="electronic"><day>14</day><month>03</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-03-22" publication-format="electronic"><day>22</day><month>03</month><year>2023</year></pub-date><volume>28</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>53</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2023-02-23"><day>23</day><month>02</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-03-10"><day>10</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Efremov D.O., Khuramshin A.R., Кozlov S.S., Gulyaev N.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Ефремов Д.О., Хурамшин А.Р., Козлов С.С., Гуляев Н.И.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Efremov D.O., Khuramshin A.R., Кozlov S.S., Gulyaev N.I.</copyright-holder><copyright-holder xml:lang="ru">Ефремов Д.О., Хурамшин А.Р., Козлов С.С., Гуляев Н.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-03-22"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/278272">https://rjeid.com/1560-9529/article/view/278272</self-uri><abstract xml:lang="en"><p>This article describes a clinical case of mixed infection with COVID-19 and tropical malaria. Patient Z., 37 years old, arrived from the Central African Republic with a diagnosis of “New coronavirus infection COVID-19, confirmed (PCR RNA SARS-CoV-2‘+’ from January 27, 2022) mild form.” During an objective examination, the subictericity of the sclera and skin integument attracted attention. During thermometry, an increase in body temperature to 39.0°C was found. Consciousness at the level of somnolence was observed. Hemodynamics was unstable, with episodes of arterial hypotension; heart rate was 96 beats per minute. Respiratory rate was 24 breaths in 1 minute, SpO<sub>2</sub> 95%, and with inspiratory dyspnea. According to the patient’s laboratory study results, severe thrombocytopenia, apparent signs of hepatic and renal insufficiency, hyperbilirubinemia, increased concentrations of C-reactive protein, and procalcitonin were revealed. A differential diagnostic search was performed between acute viral hepatitis and malaria. Blood microscopy revealed young trophozoites of <italic>Plasmodium falciparum</italic> (++++) using the thick drop method. Antimalarial therapy with Malacur was prescribed, which was then replaced with parenteral Quinine followed by mefloquine. In parallel, extracorporeal detoxification operations were performed. The patient’s condition was stabilized against adequate etiotropic therapy and complex intensive care measures. On the 40th day, the patient was discharged restored health.</p> <p>The purpose of demonstrating a clinical case is to attract increased attention to the problem of imported cases of malaria, which, when combined with COVID-19 infection, may remain unrecognized for a long time, especially in cases where the diagnosis of COVID-19 receives rapid laboratory confirmation.</p> <p>Adequate and timely antimalarial therapy, including a complex of intensive care measures supplemented with extracorporeal detoxification methods, is the basis for a successful outcome in patients with severe malaria with the development of severe complications.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен клинический случай микст-инфекции COVID-19 и тропической малярии.</p> <p>Больной З., 37 лет, прибыл из Центральноафриканской Республики с диагнозом «Новая коронавирусная инфекция COVID-19, подтверждённая (ПЦР РНК SARS-CoV-2 «+» от 27.01.2022), лёгкая форма». При объективном осмотре обращали на себя внимание субиктеричность склер и кожных покровов, повышение температуры тела до 39,0°С. Сознание на уровне сомноленции. Гемодинамика нестабильная, эпизоды артериальной гипотензии. Частота сердечных сокращений 96 в минуту; частота дыхательных движений 24 в минуту; сатурация (SpO<sub>2</sub>) 95%; явления инспираторной одышки. По данным лабораторного исследования выявлены тяжёлая тромбоцитопения, выраженные признаки печёночно-почечной недостаточности, гипербилирубинемия, повышение концентрации C-реактивного белка, прокальцитонина. Дифференциально-диагностический поиск был проведён между острыми вирусными гепатитами и малярией. При микроскопии крови методом толстой капли выявлены юные трофозоиты <italic>Plasmodium falciparum</italic> (++++). Противомалярийная терапия была дополнена экстракорпоральной детоксикацией. На фоне адекватной этиотропной терапии, комплексных мероприятий интенсивной терапии состояние пациента стабилизировано, и на 40-е сутки он выписан из стационара с восстановлением здоровья.</p> <p>Цель демонстрации клинического примера ― привлечение внимания к проблеме завозных случаев малярии, которые при сочетанном течении с инфекцией COVID-19, особенно при её быстром лабораторном подтверждении, могут продолжительное время оставаться нераспознанными.</p> <p>Адекватная и своевременная противомалярийная терапия, объединяющая комплекс мероприятий интенсивной терапии и методы экстракорпоральной детоксикации, является основой благополучного исхода у пациентов с осложнениями, развившимися на фоне тяжёлого течения малярии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>tropical malaria</kwd><kwd>Plasmodium falciparum</kwd><kwd>mixed infection</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>тропическая малярия</kwd><kwd>Plasmodium falciparum</kwd><kwd>микст-инфекция</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Zhou F, Yu T, Du R, et al. 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