Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector11754510.17816/EID117545Research ArticleSensitivity of pathogenic and opportunistic microorganisms to probiotic strains in the light of personalized probiotic therapyParakhinaAnastasia I.an.parakhina@mail.ruhttps://orcid.org/0000-0003-1108-0811ParakhinaLarisa I.myinspirationmy@mail.ruhttps://orcid.org/0000-0003-2428-9032TroshinaDarya A.troshina.darya92@mail.ruhttps://orcid.org/0000-0003-3658-2674LevinaKaterina E.pumpum235@gmail.ruhttps://orcid.org/0000-0001-6550-2931PimenovaYulia A.<p>MD, Cand. Sci. (Med.), Associate Professor</p>medic.81@mail.ruhttps://orcid.org/0000-0001-8722-2746KotenevaElena N.<p>MD</p>lenakoteneva@rambler.ruhttps://orcid.org/0000-0002-9901-2292EvstropovAleksandr N.<p>MD, Dr. Sci. (Med.), Professor</p>evstrop@gmail.comhttps://orcid.org/0000-0002-1551-3154ZakharovaLiudmila N.<p>MD, Cand. Sci. (Med.), Associate Professor</p>nisngma@ngs.ruhttps://orcid.org/0000-0001-6051-2380MironovAndrey Yu.<p>MD, Dr. Sci. (Med.), Professor</p>andy.60@mail.ruhttps://orcid.org/0000-0002-8544-5230SuranovaTatyana G.<p>MD, Cand. Sci. (Med.), Associate Professor</p>suranovatatiana@mail.ruhttps://orcid.org/0000-0003-3411-1027Novosibirsk State Medical UniversityCenter of Hygiene and Epidemiology in the Novosibirsk RegionMoscow Research Institute of Epidemiology and Microbiology named after G.N. GabrichevskyAcademy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies150220232752802891412202216012023Copyright © 2023, Eco-vector2023<p><strong><em>BACKGROUND</em></strong><em>:</em> Resistance of microorganisms to antimicrobial drugs (AMP) is one of the global problems of modern medicine, which poses a serious threat to human health. The formation of the resistance of pathogens to AMP forces us to look for new ways to combat them. Probiotic therapy is one of the promising and safe methods of treating many infectious diseases.</p>
<p><strong><em>AIM</em></strong><em>:</em> This study assesses the sensitivity of clinical strains of pathogenic and opportunistic bacteria and fungi to microorganisms that are part of probiotic preparations.</p>
<p><strong><em>MATERIALS AND METHODS</em></strong><em>:</em> The sensitivity of 93 cultures of pathogenic and opportunistic microorganisms (UPM) isolated from the feces of patients with intestinal dysbiosis to strains of probiotic bacteria isolated from commercial probiotic preparations was studied: <em>Lactobacillus plantarum 8RA-3, Escherichia coli M-17, Bacillus subtilis</em> strain <em>VKPM B-10641, Enterococcus faecium SF-68, Saccharomyces boulardii CNCM I-745</em> by the delayed antagonism method.</p>
<p><strong><em>RESULTS</em></strong><em>:</em> Pathogenic microorganisms showed low and moderate sensitivity to the probiotic strain of <em>L. plantarum</em>. Sensitivity to the probiotic strain of <em>B. subtilis</em> was detected in <em>Staphylococcus aureus</em> strains, low or completely absent in Pseudomonas aeruginosa, <em>Klebsiella</em> spp., <em>Serratia marcescens</em>. The most sensitive to the probiotic strain were clinical strains of <em>E. coli</em>.</p>
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