Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector10942210.17816/EID109422Research ArticleMonitoring results of the incidence of non-polio enterovirus infection in the pre-pandemic and pandemic periodsDanshinaEkaterina A.kotya9530@mail.ruhttps://orcid.org/0000-0002-3382-2161MironovAndrey Y.<p>MD, Dr. Sci. (Med.), Professor</p>andy.60@mail.ruhttps://orcid.org/0000-0002-8544-5230SuranovaTatiana<p>MD, PhD, Professor of the Department of hygiene, epidemiology and infectious diseases, Academy of Postgraduate Education</p>suranovatatiana@mail.ruhttps://orcid.org/0000-0003-3411-1027KuyarovAlexandr V.<p>Dr. Sci. (Med.), Professor</p>kujarov@mail.ruhttps://orcid.org/0000-0001-8388-9607Center for Hygiene and Epidemiology in Khanty-Mansiysk Autonomous Okrug-YugraSurgut State University, SurgutMoscow Research Institute of Epidemiology and Microbiology named after G.N. GabrichevskyAcademy of Postgraduate Education of the Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical TechnologiesSurgut State University2710202227289972007202219092022Copyright © 2022, Eco-vector2022<p><em>BACKGROUND:</em> The study presents the results of monitoring the incidence of non-polio enterovirus infection in the pre-pandemic and pandemic periods in KhantyMansi Autonomous OkrugYugra (20112021).</p>
<p><em>AIM:</em> To analyze the incidence of non-polio EVI in the urban population of KhantyMansi Autonomous OkrugYugra for 20112021.</p>
<p><em>MATERIALS AND METHODS:</em> A retrospective analysis of the manifestations of the epidemic process of non-polio enterovirus infection was conducted, and the results of virological monitoring were presented.</p>
<p><em>RESULTS:</em> The total incidence of EVI was predominantly shared by the urban population with predominance of children aged 6 years and school children. In the period 20202021, the low incidence of EVI was due to ongoing anti-epidemic measures against COVID-19 and was accompanied by the spread of enterovirus CVA6 serotype, which can effectively implement the aspiration mechanism of the transmission of the infectious agent and cause respiratory and exanthemic diseases. The spread of CVA6 was affected by an increase in the migration activity of the population, due to the partial lifting of restrictions and an increase in the non-immune stratum of the population and a decrease in the incidence of EVI in 2020. The results of the study will contribute to the adoption of measures leading to a decrease in the incidence of EVI in the KhantyMansiysk Autonomous Okrug and rational planning of preventive measures by improving the information and diagnostic subsystems of epidemiological surveillance.</p>
<p><em>CONCLUSION:</em> To solve the tasks, further investigation of the spectrum of enteroviruses circulating in the KhantyMansiysk Autonomous Okrug, frequency of their occurrence in subclinical forms of EVI and as etiological agents of enteroviral meningitis, development of a molecular genetic typing technique using the technology of mass parallel high-throughput sequencing, and study of molecular genetic characteristics is necessary. These will reduce the risks of EVI in the post-pandemic period, ensure the sanitary and epidemiological well-being of the population, and prevent EVI spread in the KhantyMansiysk Autonomous Okrug.</p>non-polio enterovirusesCVA6enterovirus infectionenterovirus vesicular stomatitis with exanthemaenterovirus vesicular pharyngitisenterovirus meningitisнеполиомиелитные энтеровирусыСVA6энтеровирусная инфекцияэнтеровирусный везикулярный стоматит с экзантемойэнтеровирусный везикулярный фарингитэнтеровирусный менингит[Kozlovskaya OV, Katanakhova LL, Kamka NN, Evseeva AN. Epidemiological, clinical and diagnostic features of enterovirus infection among children and adults. Vestnik SurGU. Medicina. 2018;(2):56–60. (In Russ).][Bubba L, Broberg EK, Jasir A, et al. Enterovirus study collaborators. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study. Lancet Infect Dis. 2020;20(3):350–361. doi: 10.1016/S1473-3099(19)30566-3][Golitsyna LN, Zverev VV, Selivanova SG, et al. Etiological structure of enterovirus infections in the Russian Federation in 2017–2018. Public Health and Life Environment – PH&LE. 2019;(8):30–38. (In Russ). doi: 10.35627/2219-5238/2019-317-8-30-38][Zhukova LI, Rafeenko GK, Shagina AF, Vanyukov AA. Long-term epidemiological monitoring and clinical characteristics of non-polio enterovirus infections in the Krasnodar region. Epidemiology and infectious diseases. Topical issues. 2021;11(2):9–11. doi: 10.18565/epidem.2021.11.2.22-8 (In Russ).][Lobzin YuV, Skripchenko NV, Murina EA. Enteroviral infections: a guide for physicians. St. Petersburg: NIIDI; 2012. 432 p. (In Russ).][Vorobyev AA, editor. Medical microbiology, virology and immunology. 3rd ed. Moscow: MIA; 2022. 704 p. (In Russ).][Danshina EA, Kuyarov AV, Saigusheva LA, Kuyarov AA. The prevalence of enterovirus infection among residents of the urbanized North. Infectious diseases in the modern world: epidemiology, diagnosis, treatment and prevention. In: Pokrovsky VI, editor. Proceedings of the 12th Annual All-Russian Internet Congress on Infectious Diseases with International Participation. Moscow; 2020. P:67. (In Russ).][Korukluoglu G, Ozdemirer U, Bayrakdar F, et al. Detection of non-polio and polio enteroviruses in Acute Flaccid Paralysis surveillance in Turkey. Acta Microbiol Immunol Hung. 2021;68(2): 92–98. doi: 10.1556/030.2021.01353][Nikiforov VV, Suranova TG, Mironov AYu, Zabozlaev FG. New coronavirus infection (COVID-19): etiology, epidemiology, clinic, diagnosis, treatment and prevention. Moscow: Academy of Postgraduate Education of the FNKTs FMBA of Russia; 2020. 55 p. (In Russ).][Tamura K, Peterson D, Peterson N, et al. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28(10):2731–2739. doi: 10.1093/molbev/msr121]