Цитохромы P450: особенности механизмов катализа и электрокатализа для создания биосенсоров и биореакторов

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Аннотация

Цитохромы P450 - уникальное семейство ферментов, обнаруженное во всех царствах живых существ (у животных, бактерий, растений, грибов, архей). Основной функциональной ролью цитохромов P450 является биотрансформация экзогенных и эндогенных соединений. Данный обзор посвящен проблеме повышения эффективности электрокатализа цитохромами P450, которые обладают уникальными возможностями как для создания биосенсоров, так и для биотехнологического применения. В работе рассмотрены основные способы создания реконструированных и электрохимических каталитических систем на основе цитохромов P450, а также современные тенденции и подходы к практическому применению цитохромов P450.

Об авторах

П. И Королева

Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича

119121 Москва, Россия

Т. В Булко

Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича

119121 Москва, Россия

Л. Е Агафонова

Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича

119121 Москва, Россия

В. В Шумянцева

Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича;Российский национальный исследовательский медицинский университет имени Н.И. Пирогова

Email: viktoria.shumyantseva@ibmc.msk.ru
119121 Москва, Россия;117997 Москва, Россия

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