Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development

V. S. Frolova; Фролова В. С.; A. D. Ivanova; Иванова А. Д.; M. S. Konorova; Конорова М. С.; Yu. B. Shmukler; Шмуклер Ю. Б.; D. A. Nikishin; Никишин Д. А.

doi:10.31857/S023347552306004X

Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development

Autores: Frolova V.S.¹, Ivanova A.D.¹, Konorova M.S.¹, Shmukler Y.B.², Nikishin D.A.¹^,2
Afiliações:
1. Lomonosov Moscow State University
2. Koltzov Institute of Developmental Biology, Russian Academy of Sciences
Edição: Volume 40, Nº 6 (2023)
Páginas: 456-462
Seção: Articles
URL: https://rjeid.com/0233-4755/article/view/667326
DOI: https://doi.org/10.31857/S023347552306004X
EDN: https://elibrary.ru/GLJNWH
ID: 667326

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Resumo

Serotonin is a regulator of early embryonic development and has a fully functional system in preimplantation mammalian embryos. In this work, we described the spatial distribution of serotonin, the vesicular monoamine transporter VMAT2, and the serotonin receptors 5-HT_1D and 5-HT_2A at different stages of early mouse embryonic development. Serotonin, the VMAT2 transporter, and the 5-HT_1D receptor are visualized in the cortical compartment of cells, whereas the 5-HT_2A receptor has a more uniform distribution throughout the cytoplasm. Comparison of the sizes of the immunoreactive particles showed that there are no statistically significant differences between serotonin and the VMAT2 transporter, which may indicate the presence of specific vesicles containing serotonin. In addition, the two serotonin receptors, 5-HT_1D and 5-HT_2A, showed a markedly different pattern of immunoreactivity, which may indicate that they simultaneously serve different functions in early embryogenesis.

Palavras-chave

neurotransmitters, serotonin, serotonergic system, preimplantation embryos, mouse

Bibliografia

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