Synthesis and Properties of N-Substituted Purpuric Acid Derivatives and Their 2-Thioanalogues

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Abstract

A new route was developed for the synthesis of N-substituted derivatives of purple acid based on the condensation of methylene-active barbituric acids with the corresponding derivatives of 5-hydroxyiminobarbituric acid. 2-Thioanalogs of purple acid were obtained for the first time using a similar method. The spectral properties and hydrolytic stability of the synthesized purpurates were studied.

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About the authors

K. A. Krasnov

Golikov Scientific and Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

Author for correspondence.
Email: institute@toxicology.ru
ORCID iD: 0000-0003-1503-2243
Russian Federation, Saint Petersburg, 192019

K. A. Feklistova

Golikov Scientific and Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

Email: institute@toxicology.ru
ORCID iD: 0009-0006-3670-2145
Russian Federation, Saint Petersburg, 192019

A. A. Krasnova

Golikov Scientific and Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

Email: institute@toxicology.ru
ORCID iD: 0009-0004-1666-2161
Russian Federation, Saint Petersburg, 192019

V. T. Papp

Golikov Scientific and Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

Email: institute@toxicology.ru
Russian Federation, Saint Petersburg, 192019

S. S. Gaft

Golikov Scientific and Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia

Email: institute@toxicology.ru
ORCID iD: 0009-0008-5092-8161
Russian Federation, Saint Petersburg, 192019

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3. Scheme 2.

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4. Fig. 1. Absorption spectra of compounds 2a, 5e, 5i at a concentration of 1 · 10-4 mol/L (water, pH = 7).

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