Supramolecular systems based on sodium alginate and viologen calyx[4]resorcinol for encapsulation of hydrophobic compounds

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Abstract

The work is devoted to the study of a supramolecular system based on viologen calix[4]resorcinol and sodium alginate in an aqueous medium using a set of physicochemical methods. It was established that sodium alginate and viologen calix[4]resorcinol form stable nanoparticles capable of encapsulating hydrophobic biologically active substances in the range of macrocycle:polymer concentration ratios from 1:2 to 1:10. The study of the cytotoxic properties of these nanoparticles in the presence of encapsulated substrates showed an increase in the selectivity of the action of quercetin and oleic acid against M-HeLa tumor cells by 2.47 and 1.14 times, respectively.

About the authors

R. R Kashapov

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

Email: kashapov@iopc.ru

Yu. S. Razuvaeva

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. Yu. Ziganshina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. S Sapunova

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

A. D Voloshina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

V. V Salnikov

Kazan Institute of Biochemistry and Biophysics, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

L. Ya. Zakharova

A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

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