THE EVALUATION OF RISK OF DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA ON THE BASIS OF POLYMORPHISM OF GENE TNFA

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The bronchial asthma is one of the most widespread multi-factorial diseases developing in interaction of environmental and genetic factors. The purpose of this study was to analyze association of polymorphism of gene TNFA with risk of development of bronchial asthma considering clinical form of disease. The polymerase chain reaction technique was applied to analyze polymorphic locus rs1800629 of gene TNFA in patients with bronchial asthma (n=133) and control group (n=195). The analysis of rate of polymorphism of gene TNFA established reliable increasing of rate of allele A in group of patients with bronchial asthma as compared with control sample. According the coefficient of chances ratio, the risk of development of bronchial asthma if there is allele A of polymorphic locus rs1800629 of gene TNFA increases more than twice (OR=2,53; 95% CI 1,45-4,43). At that, various firms of bronchial asthma have specific features in distribution of rates of genotypes of polymorphic locus rs1800629 of gene TNFA. It is demonstrated that among agents of genotypes GA of polymorphic modification of rs1800629 of gene TNFA patients with mixed form of bronchial asthma were found more frequently than among agents of genotypes GG. The obtained results provide ground to suppose that polymorphic modification of rs1800629 of gene TNFA shows certain damaging effect under various clinical forms of bronchial asthma.

Sobre autores

G. Mukhammadieva

Ufa Research Institute of Labor and Human Ecology

Autor responsável pela correspondência
Email: ufniimt@mail.r
Rússia

T. Kutlina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
Rússia

D. Karimov

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
Rússia

Ya. Valova

Ufa Research Institute of Labor and Human Ecology; Bashkir State University

Email: noemail@neicon.ru
Rússia

P. Serebryakov

The F.F. Erisman Federal Research Сenter of Hygiene

Email: noemail@neicon.ru
Rússia

A. Melent’Ev

The F.F. Erisman Federal Research Сenter of Hygiene

Email: noemail@neicon.ru
Rússia

A. Bakirov

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
Rússia

A. Shagalina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
Rússia

E. Idiyatullina

Ufa Research Institute of Labor and Human Ecology

Email: noemail@neicon.ru
Rússia

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Declaração de direitos autorais © Mukhammadieva G.F., Kutlina T.G., Karimov D.O., Valova Y.V., Serebryakov P.V., Melent’Ev A.V., Bakirov A.B., Shagalina A.U., Idiyatullina E.F., 2020

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